Objective Cellular differentiation from stem cells to fully functional mature cells is a multi step process executed by complex transcription programs. Once differentiated, cells must faithfully maintain their identity through cellular memory mechanisms. The utilisation of genetic information stored in linear DNA sequence occurs within the three dimensional context of chromatin, chromosomes and the nucleus, all of which contribute to gene regulation mechanisms. The main aim of this ITN is to get a comprehensive view on the mechanisms controling gene expression during cell differentiation by integrating studies on multiple regulatory levels from DNA binding transcription factors through to nuclear organization. We will take a multi-faceted approach addressing the functions of: (i) transcription factors and their co-factors (ii) chromatin domains and histone variants, (iii) epigenetic mechanisms of cellular memory and identity, (iv) global gene interactions in nuclear space and (iv) nuclear territories of gene activity. Genomics approaches will be employed to describe global changes in gene target networks and gene interactions in the nucleus during ES cell differentiation into the hepatic, neuronal and hematopoietic lineages. Proteomics will be employed for the characterization of transcription factor and epigenetic modifying complexes and of the in vivo protein composition of specialized chromatin domains. The research activities of this ITN are organized in the context of a multidisciplinary Training Program, which provides unique opportunities for the training of early stage researchers to address fundamental biological questions with far reaching implications in biotechnology and human health. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsnatural sciencesbiological sciencesgeneticsDNAmedical and health sciencesmedical biotechnologycells technologiesstem cellsnatural sciencesbiological sciencesgeneticschromosomesnatural sciencesbiological sciencesgeneticsepigenetics Keywords chromatin epigenetics genomics nuclear structure stem cells transcription factors Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) PEOPLE-2007-1-1-ITN - Marie Curie Action: " Networks for Initial Training" Call for proposal FP7-PEOPLE-2007-1-1-ITN See other projects for this call Funding Scheme MC-ITN - Networks for Initial Training (ITN) Coordinator BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING Address Fleming street 34 16672 Vari-athens Greece See on map Region Αττική Aττική Ανατολική Αττική Activity type Research Organisations Administrative Contact John Strouboulis (Dr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 712 929,95 Participants (7) Sort alphabetically Sort by EU Contribution Expand all Collapse all IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON Greece EU contribution € 161 483,30 Address Soranou efesiou 4 115 27 Athina See on map Region Αττική Aττική Κεντρικός Τομέας Αθηνών Activity type Research Organisations Administrative Contact Dimitris Thanos (Prof.) Links Contact the organisation Opens in new window Website Opens in new window KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW Netherlands EU contribution € 204 047,79 Address Kloveniersburgwal 29 het trippenhuis 1011 JV Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Other Administrative Contact Don Van Velzen (Mr.) Links Contact the organisation Opens in new window Website Opens in new window LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN Germany EU contribution € 205 009,20 Address Geschwister scholl platz 1 80539 Muenchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Axel Imhof (Prof.) Links Contact the organisation Opens in new window Website Opens in new window MEDICAL RESEARCH COUNCIL United Kingdom EU contribution € 214 480,19 Address 20 park crescent W1B 1AL London See on map Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Ana Pombo (Dr.) Links Contact the organisation Opens in new window Website Opens in new window THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD United Kingdom EU contribution € 212 830,19 Address Wellington square university offices OX1 2JD Oxford See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Activity type Higher or Secondary Education Establishments Administrative Contact Philippa Kraftl (Ms.) Links Contact the organisation Opens in new window Website Opens in new window FONDAZIONE TELETHON ETS Italy EU contribution € 381 339,19 Address Via varese 16/b 00185 Roma See on map Region Centro (IT) Lazio Roma Activity type Research Organisations Administrative Contact Valerio Orlando (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Source Bioscience plc United Kingdom EU contribution € 207 880,19 Address Orchard place, business park 1 NG8 6PX Nottingham See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Robert Bakewell (Mr.) Links Contact the organisation Opens in new window Website Opens in new window
