Identification and characterization of targets for the treatment of severe infections caused by Streptococcus pyogenes

Informations projet

STREPSEP

N° de convention de subvention: 219261

Projet clôturé

Date de début 1 Août 2008

Date de fin 31 Juillet 2010

Financé au titre de

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Coût total € 176 753,90

Contribution de l’UE € 176 753,90

Coordonné par

MAX IV Laboratory, Lund University
Suède

Objectif

Life-threatening complications from bacterial infections, such as sepsis and septic shock, are the second leading cause of death among patients in non-coronary intensive care units killing up to 146 000 patients each year in Europe. These alarming findings prompted many research groups, to search for novel strategies to treat severe infectious diseases. Many of these approaches are focused on so-called “host effector systems”, since evidence has accumulated that complications from an infection are caused by an over-stimulation of host defense systems that are modulated by bacteria or bacterial products. In severe infections, such as sepsis and septic shock, vascular leakage, increased cytokine levels, and coagulation/fibrinolysis dysfunction are often observed. Thus, the research projects presented in this application focus on the identification and characterization of molecular mechanisms that lead to these complications with a focus on severe infections caused by the human pathogen Streptococcus pyogenes. The results obtained from such investigations could be used for the discovery of novel treatments in infectious diseases.

Champ scientifique (EuroSciVoc)

CORDIS classe les projets avec EuroSciVoc, une taxonomie multilingue des domaines scientifiques, grâce à un processus semi-automatique basé sur des techniques TLN. Voir: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

• sciences naturelles › sciences biologiques › microbiologie › bactériologie
• sciences médicales et de la santé › sciences de la santé › maladie infectieuse
• sciences médicales et de la santé › médecine clinique › médecine intensive

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Mots‑clés

• Host/parasite interactions
• Infections
• inflammation
• sepsis
• severe infectious diseases

Programme(s)

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thème(s)

• PEOPLE-2007-2-1.IEF - Marie Curie Action: "Intra-European Fellowships for Career Development"

Appel à propositions

FP7-PEOPLE-2007-2-1-IEF
Voir d’autres projets de cet appel

Régime de financement

MC-IEF -

Coordinateur

MAX IV Laboratory, Lund University

• Contribution de l’UE: € 176 753,90
• Adresse: Paradisgatan 5c ; 22100 LUND ; Suède
• Région: Södra Sverige › Sydsverige › Skåne län
• Type d’activité: Établissements d’enseignement supérieur ou secondaire
• Coût total: Aucune donnée