Objective
The full potential of coherent-gated functional imaging capabilities in scattering media has not been yet realized. Particularly, optical coherence tomography and microscopy (OCT) present a promising investigational tool in cellular biology, especially when combined with principles of Information Theory for analysing the measured functional OCT (fOCT) signal. This research aims to explore the dynamic non-linear response of tissues and cells excited by an optical pump signal by means of optical coherence imaging and spectroscopy. Sophisticated path-length and transverse-direction-resolved studies of measures such as water absorption and polarization states of reflected light will be conducted.
A theoretical analysis will be directed towards:
(i) deriving the Volterra kernels associated with the non-linear response of the biological medium as well as performing importance sampling Monte-Carlo light-tissue simulations in order to understand the relationship between the medium properties and the measured fOCT signal;
(ii) the use of Shannon and Fisher information quantities to determine the information amount conveyed by the fOCT signal.
The research results not only will set the theory of the inverse problem in fOCT on a firmer foundation, but also will significantly affect the safety and optimisation of the optical feedback control of therapeutic lasers, for instance in laser ablation procedures. This interdisciplinary proposal brings together Prof. Brett Bouma's group at Harvard Medical School and Prof. Theo Lasser 's group at the EPFLausanne, to combine their extensive expertise on OCT and microscopy with the objectives of adding scientific and complimentary competencies to the career of the applicant, Alberto Bilenca, extending his international research experience and providing him with new knowledge in the area of functional optical coherence imaging, which will be gained by the EPFL group, as well as will enable Alberto to establish his own academic career.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences physical sciences optics microscopy
- natural sciences computer and information sciences software software applications simulation software
- natural sciences physical sciences optics laser physics
- natural sciences physical sciences optics spectroscopy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-6
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
OIF - Marie Curie actions-Outgoing International Fellowships
Coordinator
LAUSANNE
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.