Objective
Asymmetric cell division, in which a cell divides into two cells of different developmental fate, is a fundamental mechanism for generating cell diversity. Although the significance of asymmetric cell division for development of multicellular organisms is widely recognized, asymmetric nature of stem cell division particularly attracts a great deal of attention because stem cells are sources of diverse cells in multicellular organisms and are valuable in regenerative medicine. Therefore, elucidation of the molecular mechanism governing asymmetric cell division will lead to not only comprehension of mechanism by which multicellular organisms are constructed but also improvement of therapy with stem cells.
To divide asymmetrically, cells must establish an axis of polarity to localize cell fate determinants to one side of the cells. During cytokinesis, these determinants are then segregated into one of the two daughter cells to give specific characteristics to only one cell. In the peripheral nervous system, sensory organ precursor (SOP) cells give rise to the four cells, two outer cells (hairs and sockets) and two inner cells (neurons and sheaths), to make up the external sensory (ES) organs through a series of asymmetric cell division. Several such cell fate determinants have been identified from Drosophila mutants with morphological defects of ES organs and the molecular machinery responsible for their asymmetric segregation is beginning to be unraveled in SOP cell lineage.
This project will take a novel systematic approach, genome wide RNA interference (RNAi) screen, to identify many other participants in the process of asymmetric cell division using Drosophila SOP cells. After the identification of the novel molecules responsible for asymmetric cell division through the screen, we plan to characterize the novel participants in fly SOP cells in detail, and then analyze the function of the vertebrate orthologue using mice lacking the molecules.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences medical biotechnology cells technologies stem cells
- natural sciences biological sciences genetics RNA
- natural sciences biological sciences genetics genomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-7
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IIF - Marie Curie actions-Incoming International Fellowships
Coordinator
VIENNA
Austria
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.