The role of natural killer T cells in the early stages of the herpes simplex virus infection in skin

Información del proyecto

NKT IN HERPES

Identificador del acuerdo de subvención: 221576

Proyecto cerrado

Fecha de inicio 1 Enero 2009

Fecha de finalización 31 Mayo 2011

Financiado con arreglo a

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Coste total € 179 588,95

Aportación de la UE € 179 588,95

Coordinado por

KAROLINSKA INSTITUTET
Sweden

Objetivo

The aim of this project is to examine how the local skin microenvironment influences the generation of antiviral immune responses following herpes simplex virus type 2 (HSV-2) infection. Genital herpes, caused primarily by HSV-2, has a worldwide prevalence and is the leading cause of genital ulcers. An increasing number of clinical and epidemiological studies indicate that a recent genital HSV-2 infection increases the risk of HIV acquisition and transmission by up to 3-fold. Therefore, further studies that examine the local immune responses to HSV-2 infection are necessary to elucidate the mechanisms of enhanced risk of HIV-1 acquisition and reveal possible strategies for the development of an effective HSV vaccine. Our project will focus in particular on the responses of human natural killer T (NKT) cells, which are poised to respond within hours of activation and can rapidly modulate cellular immune responses. We will examine the ability of NKT cells to respond directly to virus infection and how the virus can affect their function. In addition, we will investigate how cutaneous immune cell types influence NKT cells and their ability to modulate appropriate cellular responses against HSV-2 infection. A three-dimensional organotypic culture model of skin will be utilised to examine these interactions in a physiologically relevant setting, obviating the need for the use of animal models. This study will provide critical information on how the immunomodulatory activities of NKT cells could be utilised as a viable strategy for the enhancement of local virus-specific immunity and thereby develop better genital herpes vaccines.

Ámbito científico

• natural sciences › biological sciences › microbiology › virology
• medical and health sciences › basic medicine › immunology
• medical and health sciences › health sciences › infectious diseases › RNA viruses › HIV
• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmaceutical drugs › vaccines
• medical and health sciences › health sciences › infectious diseases › DNA viruses

Palabras clave

• Herpes
• Immunology
• Infections

Programa(s)

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Tema(s)

• PEOPLE-2007-4-2.IIF - Marie Curie Action: "International Incoming Fellowships"

Convocatoria de propuestas

FP7-PEOPLE-2007-4-2-IIF
Consulte otros proyectos de esta convocatoria

Régimen de financiación

MC-IIF - International Incoming Fellowships (IIF)

Coordinador

KAROLINSKA INSTITUTET

• Aportación de la UE: € 179 588,95
• Dirección: Nobels Vag 5 ; 17177 Stockholm ; Suecia
• Región: Östra Sverige › Stockholm › Stockholms län
• Tipo de actividad: Higher or Secondary Education Establishments
• Contacto administrativo: Klas Karlsson (Mr.)
• Coste total: Sin datos