Objective Cancer chemotherapy has a key role in the successful treatment of a number of childhood cancers. Nevertheless, at least 20% of patients are not cured by current therapies and a significant number experience debilitating toxicities. Given the high cure rates and potential life-span of survivors of childhood cancer, it is particularly important to minimize the impact of potential chronic toxicities. For several of the most widely-used drugs, little is known about their pharmacokinetics and metabolism in children, particularly very young children (<3 years). There are many examples where such knowledge has been used to optimize the use of chemotherapeutic drugs, both to avoid toxicity and to maximize the therapeutic effect. The need for further research to investigate these drugs in children is acknowledged in the Priority List for Studies into Paediatric Medicinal Products, issued by the EMEA. Doxorubicin is on this list and is one of the most important drugs used in the treatment of childhood cancers. Several national groups have been successful in studying the pharmacology of drugs used in paediatric oncology. However, in order to recruit sufficient patient numbers for meaningful studies it is necessary to establish a wider group, bringing together the successful elements of established national organizations. The EPOC group combines leading pharmacologists, paediatric oncologists, regulatory organizations and a management structure which will successfully deliver data of appropriate quality on which to base future clinical use of this drug and to meet the demands of the EMEA priority list. Such data will form the basis of future applications for Paediatric Usage Marketing Authorization for doxorubicin. The overall aim of the consortium is to provide data that will guide the optimal use of this drug in the clinic, and also meet the regulatory requirements of the EMA. Keywords Cancer Children Pharmacogenetics Pharmacokinetics Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2007-4.2-1 - Adapting off-patent medicines to the specific needs of paediatric populations Call for proposal FP7-HEALTH-2007-B See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator UNIVERSITY OF NEWCASTLE UPON TYNE EU contribution € 379 683,86 Address KINGS GATE NE1 7RU Newcastle Upon Tyne United Kingdom See on map Region North East (England) Northumberland and Tyne and Wear Tyneside Activity type Higher or Secondary Education Establishments Administrative Contact Nicola Place (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (10) Sort alphabetically Sort by EU Contribution Expand all Collapse all INSTITUTE OF CANCER RESEARCH: THE ROYAL CANCER HOSPITAL LBG Participation ended United Kingdom EU contribution No data Address OLD BROMPTON ROAD 123 SW7 3RP London See on map Region London Inner London — West Kensington & Chelsea and Hammersmith & Fulham Activity type Higher or Secondary Education Establishments Administrative Contact Yodry Vasquez (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY OF LEICESTER Participation ended United Kingdom EU contribution No data Address UNIVERSITY ROAD LE1 7RH Leicester See on map Region East Midlands (England) Leicestershire, Rutland and Northamptonshire Leicester Activity type Higher or Secondary Education Establishments Administrative Contact Marie Singer (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CANCER RESEARCH UK LBG United Kingdom EU contribution € 75 750,00 Address 2 Redman Place E20 1JQ LONDON See on map Region London Inner London — West Camden and City of London Activity type Research Organisations Administrative Contact Robina Ibanda (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data POWERTRIAL LIMITED United Kingdom EU contribution € 84 200,00 Address MARQUIS COURT UNIT A2 TEAM NE11 0RU NEWCASTLE See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Rachael Hogg (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Westfälische Wilhelms-Universität Münster Germany EU contribution € 900 467,00 Address SCHLOSSPLATZ 2 48149 MUENSTER See on map Region Nordrhein-Westfalen Münster Münster, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Carola Brieger (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI Italy EU contribution € 194 541,14 Address VIA MARIO NEGRI 2 20156 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Research Organisations Administrative Contact Maurizio D'incalci (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data AZIENDA OSPEDALE UNIVERSITA PADOVA Italy EU contribution € 71 649,00 Address VIA NICOLO GIUSTINIANI 1 35128 Padova See on map Region Nord-Est Veneto Padova Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Antonio Giona (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CONFEDERACION INTERNACIONAL DE ORGANIZACIONES DE PADRES DE NINOS CON CANCER ASOCIACION Spain EU contribution € 50 000,00 Address PLAZA PABLO PICASSO 9 3 D 46015 VALENCIA See on map Activity type Other Administrative Contact Marianne Naafs-Wilstra (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY COLLEGE LONDON EU contribution € 52 999,00 Address GOWER STREET WC1E 6BT LONDON See on map Activity type Higher or Secondary Education Establishments Administrative Contact Greta Borg-Carbott (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITE D'AIX MARSEILLE France EU contribution € 188 572,00 Address BOULEVARD CHARLES LIVON 58 LE PHARO 13284 Marseille See on map Region Provence-Alpes-Côte d’Azur Provence-Alpes-Côte d’Azur Bouches-du-Rhône Activity type Higher or Secondary Education Establishments Administrative Contact Celine Damon (Ms.) Links Contact the organisation Opens in new window Total cost No data