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Quantitative pathway analysis of natural variation in complex disease signaling in C. elegans

Objetivo

Complex human diseases account for 60% of the deaths in Europe. The genetic variation – that is the genetic make-up of all alleles at all loci - of complex disease pathways determines individual disease susceptibility and treatment prospects. Because humans are genetically diverse the EC prioritizes research which leads to a better understanding of the natural variation in genetic pathways underlying complex diseases. But for ethical reasons there is insufficient statistical power to identify these genetic mechanisms in large human populations. Therefore the extent and importance of natural variation in disease signaling pathways of complex human diseases remains largely unknown. PANACEA will investigate the influence of natural variation in genetic pathways in the worm Caenorhabditis elegans. C. elegans is an important model for the identification and characterization of genes associated with cancer in humans. Therefore PANACEA focuses on cancer signaling pathways as a prototypical example of a complex disease. The project will address two pivotal quations: i) how natural genetic variation affects complex disease signaling pathways, and ii) whether we can predict the effect of the natural genetic variation on these pathways. We will collect, store and analyse high-throughput genomic and proteomic data in genetically highly diverse populations. In conjunction with cellular developmental data we will construct a systems biology model aiming to describe and understand the effect of natural variation on cancer signaling pathways. The outcomes will provide i) an extensive data base of novel candidate genes and their genetic variation, and ii) a comprehensive systems biology analysis of how this genetic variation affects cancer development. PANACEA advances the FP6 projects ESBIC-D, CASIMIR and EURATools by providing new data and insights which will strongly benefit the field of systems biology in human health research in the EU.

Ámbito científico

Convocatoria de propuestas

FP7-HEALTH-2007-B
Consulte otros proyectos de esta convocatoria

Régimen de financiación

CP-FP - Small or medium-scale focused research project

Coordinador

WAGENINGEN UNIVERSITY
Dirección
Droevendaalsesteeg 4
6708 PB Wageningen
Países Bajos
Tipo de actividad
Higher or Secondary Education Establishments
Aportación de la UE
€ 879 919
Contacto administrativo
Rudie Jullens (Dr.)

Participantes (4)

THE UNIVERSITY OF MANCHESTER
United Kingdom
Aportación de la UE
€ 602 361
Dirección
Oxford Road
M13 9PL Manchester
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Liz Fay (Ms.)
UNIVERSITAT ZURICH
Suiza
Aportación de la UE
€ 683 475
Dirección
Ramistrasse 71
8006 Zürich
Tipo de actividad
Other
Contacto administrativo
Michael Hengartner (Prof.)
RIJKSUNIVERSITEIT GRONINGEN
Países Bajos
Aportación de la UE
€ 635 475
Dirección
Broerstraat 5
9712CP Groningen
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Jan Poutsma (Mr.)
MICROSOFT RESEARCH LIMITED
United Kingdom
Dirección
Jj Thomson Avenue 7
CB3 0FB Cambridge
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Hayley North (Ms.)