Objective A key problem in repair and functional regeneration following myocardial infarction is the inability of heart muscle tissue to regenerate itself and appropriate vascularization under conditions of increased strain caused by the reduced contractibility of the damaged heart. This frequently leads to continuous loss of functional cells, further increase of the infarct area and finally complete loss of heart function. We propose to explore possibilities for cell therapy using different procedures and sources of stem and progenitor cells. First, we will investigate factors stimulatory for stem/progenitor cell release from the bone marrow, their recruitment to the heart and the activation of resident heart stem cells. Second, we will evaluate adoptive transfer of stem/progenitor cells of different sources, from bone marrow, adult and cord blood, adipose tissue and heart tissue itself. The use of ex vivo cultured and differentiated cells including embryonic stem cells will be tested. Third, we will test genetic modification of these cells for improved differentiation, homing and tissue repair. Fourth, we will use a unique artificial scaffold material as a slow release device for factors and as a structural support material for providing the different cell preparations to the damaged areas. This scaffold will aso be used for tissue engineering in vitro followed by insertion of artficial tissue onto the infarct area. This project of high clinical importance is designed to further support the research and development needs of two SMEs, one is determined to become a supplier of growth factor cocktails for clinical stem cell culture, a second is based on the generation and supply of stem cells for clinical use. It will evaluate whether induction of repair by factors, adoptive transfer of stem/progenitor cells or engineered tissue has benefit for heart regeneration and has potential to become a future clinical standard therapy. Fields of science medical and health sciencesmedical biotechnologygenetic engineeringmedical and health sciencesmedical biotechnologytissue engineeringmedical and health sciencesmedical biotechnologycells technologiesstem cells Keywords myocard regeneration myocardial infarct neovascularization stem and progenitor cell therapy tissue engineering Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2007-2.4.2-5 - Cell therapies for the treatment of heart ischemia Call for proposal FP7-HEALTH-2007-B See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator MEDIZINISCHE UNIVERSITAET WIEN EU contribution € 464 700,00 Address SPITALGASSE 23 1090 Wien Austria See on map Region Ostösterreich Wien Wien Activity type Higher or Secondary Education Establishments Administrative Contact Erhard Hofer (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (8) Sort alphabetically Sort by EU Contribution Expand all Collapse all VIB VZW Belgium EU contribution € 300 000,00 Address SUZANNE TASSIERSTRAAT 1 9052 ZWIJNAARDE - GENT See on map Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Research Organisations Administrative Contact Peter Carmeliet (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSIDAD DE NAVARRA Spain EU contribution € 282 000,00 Address CAMPUS UNIVERSITARIO EDIFICIO CENTRAL 31080 Pamplona See on map Region Noreste Comunidad Foral de Navarra Navarra Activity type Higher or Secondary Education Establishments Administrative Contact Cristina Patsouris (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data TEL AVIV UNIVERSITY Israel EU contribution € 282 000,00 Address RAMAT AVIV 69978 Tel Aviv See on map Activity type Higher or Secondary Education Establishments Administrative Contact Lea Pais (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KLINIKUM DER UNIVERSITAET ZU KOELN Germany EU contribution € 312 000,00 Address Kerpener Strasse 62 50937 Koeln See on map Region Nordrhein-Westfalen Köln Köln, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Jutta Landvogt (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BEN-GURION UNIVERSITY OF THE NEGEV Israel EU contribution € 285 000,00 Address . 84105 Beer Sheva See on map Activity type Higher or Secondary Education Establishments Administrative Contact Daphna Tripto (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data REGION HOVEDSTADEN Denmark EU contribution € 327 000,00 Address KONGENS VAENGE 2 3400 Hillerod See on map Region Danmark Hovedstaden Nordsjælland Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Jens Kastrup (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data EUROBIOSCIENCES GMBH Germany EU contribution € 231 300,00 Address ALTENOYTHER STRASSE 10 26169 FRIESOYTHE See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Werner Luttmann (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data VIVOCELL BIOSOLUTIONS GMBH & CO KG Austria EU contribution € 216 000,00 Address STATTEGGER STRASSE 60 8045 GRAZ See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Karl-Heinz Preisegger (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
