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Therapy after heart infarct: prevention of reperfusion injury and repair by stem cell transfer

Objective

A key problem in repair and functional regeneration following myocardial infarction is the inability of heart muscle tissue to regenerate itself and appropriate vascularization under conditions of increased strain caused by the reduced contractibility of the damaged heart. This frequently leads to continuous loss of functional cells, further increase of the infarct area and finally complete loss of heart function. We propose to explore possibilities for cell therapy using different procedures and sources of stem and progenitor cells. First, we will investigate factors stimulatory for stem/progenitor cell release from the bone marrow, their recruitment to the heart and the activation of resident heart stem cells. Second, we will evaluate adoptive transfer of stem/progenitor cells of different sources, from bone marrow, adult and cord blood, adipose tissue and heart tissue itself. The use of ex vivo cultured and differentiated cells including embryonic stem cells will be tested. Third, we will test genetic modification of these cells for improved differentiation, homing and tissue repair. Fourth, we will use a unique artificial scaffold material as a slow release device for factors and as a structural support material for providing the different cell preparations to the damaged areas. This scaffold will aso be used for tissue engineering in vitro followed by insertion of artficial tissue onto the infarct area. This project of high clinical importance is designed to further support the research and development needs of two SMEs, one is determined to become a supplier of growth factor cocktails for clinical stem cell culture, a second is based on the generation and supply of stem cells for clinical use. It will evaluate whether induction of repair by factors, adoptive transfer of stem/progenitor cells or engineered tissue has benefit for heart regeneration and has potential to become a future clinical standard therapy.

Call for proposal

FP7-HEALTH-2007-B
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

MEDIZINISCHE UNIVERSITAET WIEN
Address
Spitalgasse 23
1090 Wien
Austria
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 464 700
Administrative Contact
Erhard Hofer (Prof.)

Participants (8)

VIB VZW
Belgium
EU contribution
€ 300 000
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Activity type
Research Organisations
Administrative Contact
Peter Carmeliet (Prof.)
UNIVERSIDAD DE NAVARRA
Spain
EU contribution
€ 282 000
Address
Campus Universitario Edificio Central
31080 Pamplona
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Cristina Patsouris (Dr.)
TEL AVIV UNIVERSITY
Israel
EU contribution
€ 282 000
Address
Ramat Aviv
69978 Tel Aviv
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Lea Pais (Ms.)
KLINIKUM DER UNIVERSITAET ZU KOELN
Germany
EU contribution
€ 312 000
Address
Kerpener Strasse 62
50937 Koeln
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jutta Landvogt (Ms.)
BEN-GURION UNIVERSITY OF THE NEGEV
Israel
EU contribution
€ 285 000
Address
.
84105 Beer Sheva
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Daphna Tripto (Ms.)
REGION HOVEDSTADEN
Denmark
EU contribution
€ 327 000
Address
Kongens Vaenge 2
3400 Hillerod
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Jens Kastrup (Prof.)
EUROBIOSCIENCES GMBH
Germany
EU contribution
€ 231 300
Address
Altenoyther Strasse 10
26169 Friesoythe
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Werner Luttmann (Dr.)
VIVOCELL BIOSOLUTIONS GMBH & CO KG
Austria
EU contribution
€ 216 000
Address
Stattegger Strasse 60
8045 Graz
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Karl-Heinz Preisegger (Prof.)