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Contenido archivado el 2024-06-18

Signalling in life cycle stages of malaria parasites

Objetivo

Malaria is a major public health problem in the developing world and is endemic in many regions of India. The development of novel strategies for malaria control requires a better understanding of the biology of malaria parasites. Our project aims at bringing a significant contribution to this field, through dissecting the signalling pathways that regulate essential processes in the life cycle of malaria parasites. The proposed research will merge two lines of investigation that have thus far been conducted largely independently from each other, namely: (i) the characterisation of components of signal transduction pathways (protein kinases, nucleotide cyclases, calcium signalling mediators) in malaria parasites; (ii) the study of specific biological processes during the life cycle of malaria parasites. Merging these two fields of malaria research will ensure a high level of complementarity and synergy within the consortium. Specific workpackages will be centred on understanding signalling-dependent regulation in the following processes and stage transition within the life cycle of malaria parasites: • erythrocyte infection (invasion, parasite proliferation) • sexual development (gametocytogenesis, gametogenesis, transmission to the mosquito vector) • hepatocyte infection (invasion, parasite proliferation, egress) • membrane dynamics (trafficking, transporters) Approaches will include proteomics, reverse genetics, structural biology, and the use of animal models of malaria. The consortium is constituted of EU and Indian partners with a proven track record either in research into one of the developmental stages/processes described above, or in signal transduction in malaria parasites. The project will significantly strenghten EU-India cooperation in this highly relevant topic.

Ámbito científico

Not validated

Palabras clave

Programa(s)

Tema(s)

Convocatoria de propuestas

FP7-HEALTH-2007-B
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Régimen de financiación

CP-SICA - Collaborative project for specific cooperation actions dedicated to international cooperation partner countries (SICA)

Coordinador

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Aportación de la UE
€ 472 000,00
Dirección
RUE DE TOLBIAC 101
75654 Paris
Francia

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Región
Ile-de-France Ile-de-France Paris
Tipo de actividad
Research Organisations
Contacto administrativo
Rofigua Hakem (Ms.)
Enlaces
Coste total
Sin datos

Participantes (16)

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Última actualización: 10 Marzo 2023

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Permalink: https://cordis.europa.eu/project/id/223044/es

European Union, 2024