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Identification and validation of novel drug targets in Gram-negative bacteria by global search: a trans-system approach

Objective

Multi-drug-resistant bacterial infections are increasing at an alarming pace in both developing and developed countries and in both community and nosocomial settings. The few antimicrobial agents that have been launched during the last decade (e.g. linezolid, daptomycin) have a good activity against Gram-positive bacteria. However, multi-drug-resistant bacteria are often found among the Gram-negative group. To tackle this problem, the AntiPathoGN project proposes a novel strategy for the discovery of new antimicrobial drug targets in a number of Gram-negative bacteria. This strategy is based on a comparative, system-level analysis of molecular processes involved in pathogenicity, drug resistance, cell division and/or growth of selected pathogenic Gram-negative bacteria through a combination of computational biology, interactome discovery, in-vivo protein-blocking and structural biology techniques. This comparative analysis, at one organization level above genomics, shall permit the discovery of new potential drug targets, relevant to both species-specific and broad-spectrum antimicrobial strategies. In addition, the AntiPathoGN project will pursue the identification of novel antibacterial compounds acting against previously validated targets by screening purpose-specific libraries of products derived from natural resources and from synthetic compounds. An important aspect of the project is that more than one approach is planned for the key objectives of target identification, target validation, target characterisation, and hit finding. The AntiPathoGN consortium is composed of 1 university bringing expertises in computational biology and microbiology, 3 research centres with expertises in computational and experimental interactomics, structural biology and clinical microbiology, and 7 SMEs with records on recombinant-antibody technology, structural biology, drug discovery and clinical research. The AntiPathoGN project fully addresses topic HEALTH-2007-2.3.1-1.

Field of science

  • /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance
  • /medical and health sciences/clinical medicine/clinical microbiology
  • /natural sciences/biological sciences/molecular biology/structural biology
  • /natural sciences/biological sciences/microbiology

Call for proposal

FP7-HEALTH-2007-B
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

UNIVERSIDAD AUTONOMA DE BARCELONA
Address
Calle Campus Universitario Sn Cerdanyola V
08290 Cerdanyola Del Valles
Spain
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 966 819
Administrative Contact
Katja Schustakowitz (Ms.)

Participants (10)

FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)
Spain
EU contribution
€ 744 320
Address
Carrer Baldiri Reixac 10-12 Parc Scientific De Barcelona
08028 Barcelona
Activity type
Research Organisations
Administrative Contact
Stella Serra (Ms.)
RPS RESEARCH IBERICA SL
Spain
EU contribution
€ 419 865,72
Address
Via Augusta 21-23
08006 Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Mas Jose Manuel (Dr.)
MICROBIONTA, S.L.

Participation ended

Spain
EU contribution
€ 533 273
Address
Ronda De Poniente - Bajo C-d 4
ES28760 Tres Cantos
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Myriam De Grado (Dr.)
PROTEROS BIOSTRUCTURES GmbH
Germany
EU contribution
€ 848 840
Address
Am Klopferspitz 19
82152 Martinsried
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Dirk Ullmann (Dr.)
InterMed Discovery GmbH

Participation ended

Germany
EU contribution
€ 471 063,60
Address
Otto-hahn-strasse 15
D-44227 Dortmund
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Marc Stadler (Dr.)
BIO-XTAL SARL
France
EU contribution
€ 541 040
Address
Rue Thomas Edison 2
67450 Mundolsheim
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Laurent Vuillard (Dr.)
FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA
Spain
EU contribution
€ 356 720
Address
Carrer Rossello 149
08036 Barcelona
Activity type
Research Organisations
Administrative Contact
Emili Bargalló (Mr.)
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Germany
EU contribution
€ 698 879
Address
Im Neuenheimer Feld 280
69120 Heidelberg
Activity type
Research Organisations
Administrative Contact
Bettina Crispin (Ms.)
ANAXOMICS BIOTECH SL
Spain
EU contribution
€ 231 544,28
Address
Calle Diputacio 237, P 1 Pta 1
08007 Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Judith Farrés Marisch (Dr.)
HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH
Germany
EU contribution
€ 131 596,40
Address
Inhoffenstrasse 7
38124 Braunschweig
Activity type
Research Organisations
Administrative Contact
Michael Straetz (Dr.)