Objective
Multi-drug-resistant bacterial infections are increasing at an alarming pace in both developing and developed countries and in both community and nosocomial settings. The few antimicrobial agents that have been launched during the last decade (e.g. linezolid, daptomycin) have a good activity against Gram-positive bacteria. However, multi-drug-resistant bacteria are often found among the Gram-negative group. To tackle this problem, the AntiPathoGN project proposes a novel strategy for the discovery of new antimicrobial drug targets in a number of Gram-negative bacteria. This strategy is based on a comparative, system-level analysis of molecular processes involved in pathogenicity, drug resistance, cell division and/or growth of selected pathogenic Gram-negative bacteria through a combination of computational biology, interactome discovery, in-vivo protein-blocking and structural biology techniques. This comparative analysis, at one organization level above genomics, shall permit the discovery of new potential drug targets, relevant to both species-specific and broad-spectrum antimicrobial strategies. In addition, the AntiPathoGN project will pursue the identification of novel antibacterial compounds acting against previously validated targets by screening purpose-specific libraries of products derived from natural resources and from synthetic compounds. An important aspect of the project is that more than one approach is planned for the key objectives of target identification, target validation, target characterisation, and hit finding. The AntiPathoGN consortium is composed of 1 university bringing expertises in computational biology and microbiology, 3 research centres with expertises in computational and experimental interactomics, structural biology and clinical microbiology, and 7 SMEs with records on recombinant-antibody technology, structural biology, drug discovery and clinical research. The AntiPathoGN project fully addresses topic HEALTH-2007-2.3.1-1.
Field of science
- /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance
- /medical and health sciences/clinical medicine/clinical microbiology
- /natural sciences/biological sciences/molecular biology/structural biology
- /natural sciences/biological sciences/microbiology
Call for proposal
FP7-HEALTH-2007-B
See other projects for this call
Funding Scheme
CP-FP - Small or medium-scale focused research projectCoordinator
08290 Cerdanyola Del Valles
Spain
Participants (10)
08028 Barcelona
08006 Barcelona
Participation ended
ES28760 Tres Cantos
82152 Martinsried
Participation ended
D-44227 Dortmund
67450 Mundolsheim
08036 Barcelona
69120 Heidelberg
08007 Barcelona
38124 Braunschweig
