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Collaborative Oncological Gene-environment Study

Objective

The overarching goal of COGS is to identify individuals with an increased risk of breast, ovary and prostate cancer. Furthermore, we will evaluate the effect of inherited genetic variation on tumour characteristics and clinical outcome. We will do this through quantifying the role of genetic and environmental/lifestyle risk in the largest data set ever generated. In all, we will include over 200,000 individuals in the COGS project. We will use detailed knowledge of the architecture of genetic susceptibility and interactions with environmental/lifestyle factors which will result in much more accurate individual risk prediction and improved intervention strategies. We are taking advantage of a unique possibility by incorporating seven existing consortia into one large project – COGS. Members of these consortia have collaborated successfully over the past years and results have been presented in world leading scientific journals such as Nature, Nature Genetics and Journal of the National Cancer Institute. These papers reflect that collaboration has been ongoing and that is has so far been very successful. We will also build on an existing European Commission project, TRANSBIG, thus adding value to already spent money. Results generated through COGS will lead to an improved understanding of the biological processes that underlie carcinogenesis, that in turn could guide new therapeutic strategies. Results will also lead to the development of new tests for risk prediction for breast, ovarian and prostate cancer.

Field of science

  • /natural sciences/biological sciences/genetics and heredity
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /medical and health sciences/clinical medicine/oncology/cancer/breast cancer
  • /medical and health sciences/clinical medicine/oncology/cancer/prostate cancer

Call for proposal

FP7-HEALTH-2007-B
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

KAROLINSKA INSTITUTET
Address
Nobels Vag 5
17177 Stockholm
Sweden
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 301 573,17
Administrative Contact
Agneta Haeggstroem (Ms.)

Participants (15)

THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 3 796 030,40
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Keith Cann (Mr.)
QUEENSLAND INSTITUTE OF MEDICAL RESEARCH
Australia
Address
Herston Road, 300
QLD 4006 Herston
Activity type
Research Organisations
Administrative Contact
Bronwyn Dunphy (Ms.)
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Germany
EU contribution
€ 545 487,25
Address
Im Neuenheimer Feld 280
69120 Heidelberg
Activity type
Research Organisations
Administrative Contact
Bettina Crispin (Ms.)
FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III
Spain
EU contribution
€ 2 300 650,68
Address
Calle Melchor Fernandez Almagro 3
28029 Madrid
Activity type
Research Organisations
Administrative Contact
Juan José Collazo Nieto (Mr.)
LUNDS UNIVERSITET
Sweden
EU contribution
€ 201 534
Address
Paradisgatan 5C
22100 Lund
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Susanne André (Ms.)
HELSINGIN JA UUDENMAAN SAIRAANHOITOPIIRIN KUNTAYHTYMÄ
Finland
EU contribution
€ 201 471,60
Address
Stenbackinkatu 9
00029 Helsinki
Activity type
Research Organisations
Administrative Contact
Mari Frostell (Ms.)
STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
Netherlands
EU contribution
€ 1 087 739,60
Address
Plesmanlaan 121
1066 CX Amsterdam
Activity type
Research Organisations
Administrative Contact
Henri Van Luenen (Dr.)
FOUNDATION FOR GENOMICS & POPULATION HEALTH
United Kingdom
EU contribution
€ 490 132
Address
Worts Causeway 2
CB1 8RN Cambridge
Activity type
Research Organisations
Administrative Contact
Carol Lyon (Ms.)
KRAEFTENS BEKAEMPELSE
Denmark
EU contribution
€ 519 662,80
Address
Strandboulevarden 49
2100 Koebenhavn
Activity type
Research Organisations
Administrative Contact
Claus Skytte Rasmussen (Mr.)
BREAST INTERNATIONAL GROUP - AISBL
Belgium
EU contribution
€ 42 882,30
Address
Boulevard De Waterloo 121
1000 Bruxelles
Activity type
Research Organisations
Administrative Contact
Livia Meirsman (Ms.)
THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL
United Kingdom
EU contribution
€ 600 674,80
Address
Old Brompton Road 123
SW7 3RP London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Donna Conway (Ms.)
CENTRE DE LUTTE CONTRE LE CANCER LEON BERARD
France
EU contribution
€ 136 884
Address
Rue Laennec 28
69373 Lyon
Activity type
Research Organisations
Administrative Contact
Marina Rousseau-Tsangiris (Dr.)
University College London
United Kingdom
EU contribution
€ 170 906,40
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Greta Borg-Carbott (Ms.)
CANCER COUNCIL VICTORIA
Australia
Address
615 St Kilda Road
3004 Melbourne Victoria
Activity type
Research Organisations
Administrative Contact
Priscilla Hinds (Ms.)
THE UNIVERSITY OF WARWICK
United Kingdom
EU contribution
€ 319 872
Address
Kirby Corner Road - University House
CV4 8UW Coventry
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Peter Hedges (Dr.)