Collaborative Oncological Gene-environment Study

Project Information

COGS

Grant agreement ID: 223175

Project closed

Start date 1 May 2009

End date 31 January 2014

Funded under

• Specific Programme "Cooperation": Health

Total cost € 16 703 903,20

EU contribution € 11 715 501,00

Coordinated by

KAROLINSKA INSTITUTET
Sweden

Objective

The overarching goal of COGS is to identify individuals with an increased risk of breast, ovary and prostate cancer. Furthermore, we will evaluate the effect of inherited genetic variation on tumour characteristics and clinical outcome. We will do this through quantifying the role of genetic and environmental/lifestyle risk in the largest data set ever generated. In all, we will include over 200,000 individuals in the COGS project. We will use detailed knowledge of the architecture of genetic susceptibility and interactions with environmental/lifestyle factors which will result in much more accurate individual risk prediction and improved intervention strategies. We are taking advantage of a unique possibility by incorporating seven existing consortia into one large project – COGS. Members of these consortia have collaborated successfully over the past years and results have been presented in world leading scientific journals such as Nature, Nature Genetics and Journal of the National Cancer Institute. These papers reflect that collaboration has been ongoing and that is has so far been very successful. We will also build on an existing European Commission project, TRANSBIG, thus adding value to already spent money. Results generated through COGS will lead to an improved understanding of the biological processes that underlie carcinogenesis, that in turn could guide new therapeutic strategies. Results will also lead to the development of new tests for risk prediction for breast, ovarian and prostate cancer.

Fields of science

• medical and health sciences › clinical medicine › oncology › prostate cancer
• natural sciences › biological sciences › genetics

Keywords

• Breast cancer
• Gene-environment interaction
• Genetic susceptibility
• Ovarian cancer
• Prostate cancer
• lifestyle

Programme(s)

• FP7-HEALTH - Specific Programme "Cooperation": Health

Topic(s)

• HEALTH-2007-2.4.1-11 - Epidemiology of gene-environment interactions involved in carcinogenesis

Call for proposal

FP7-HEALTH-2007-B
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

KAROLINSKA INSTITUTET

• EU contribution: € 1 301 573,17
• Address: Nobels Vag 5 ; 17177 Stockholm ; Sweden
• Region: Östra Sverige › Stockholm › Stockholms län
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Agneta Haeggstroem (Ms.)
• Total cost: No data

Participants (15)

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

United Kingdom

• EU contribution: € 3 796 030,40
• Address: TRINITY LANE THE OLD SCHOOLS ; CB2 1TN Cambridge
• Region: East of England › East Anglia › Cambridgeshire CC
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Keith Cann (Mr.)
• Total cost: No data

QUEENSLAND INSTITUTE OF MEDICAL RESEARCH

Australia

• EU contribution: No data
• Address: Herston Road, 300 ; QLD 4006 Herston
• Activity type: Research Organisations
• Administrative Contact: Bronwyn Dunphy (Ms.)
• Total cost: No data

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG

Germany

• EU contribution: € 545 487,25
• Address: IM NEUENHEIMER FELD 280 ; 69120 Heidelberg
• Region: Baden-Württemberg › Karlsruhe › Heidelberg, Stadtkreis
• Activity type: Research Organisations
• Administrative Contact: Bettina Crispin (Ms.)
• Total cost: No data

FUNDACION SECTOR PUBLICO ESTATAL CENTRO NACIONAL INVESTIGACIONES ONCOLOGICAS CARLOS III

Spain

• EU contribution: € 2 300 650,68
• Address: C MELCHOR FERNANDEZ ALMAGRO 3 ; 28029 Madrid
• Region: Comunidad de Madrid › Comunidad de Madrid › Madrid
• Activity type: Research Organisations
• Administrative Contact: Juan José Collazo Nieto (Mr.)
• Total cost: No data

MAX IV Laboratory, Lund University

Sweden

• EU contribution: € 201 534,00
• Address: Paradisgatan 5c ; 22100 LUND
• Region: Södra Sverige › Sydsverige › Skåne län
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Susanne André (Ms.)
• Total cost: No data

HUS-YHTYMA

Finland

• EU contribution: € 201 471,60
• Address: STENBACKINKATU 9 ; 00029 Helsinki
• Region: Manner-Suomi › Helsinki-Uusimaa › Helsinki-Uusimaa
• Activity type: Research Organisations
• Administrative Contact: Mari Frostell (Ms.)
• Total cost: No data

STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS

Netherlands

• EU contribution: € 1 087 739,60
• Address: PLESMANLAAN 121 ; 1066 CX Amsterdam
• Region: West-Nederland › Noord-Holland › Groot-Amsterdam
• Activity type: Research Organisations
• Administrative Contact: Henri Van Luenen (Dr.)
• Total cost: No data

FOUNDATION FOR GENOMICS & POPULATION HEALTH

United Kingdom

• EU contribution: € 490 132,00
• Address: WORTS CAUSEWAY 2 ; CB1 8RN Cambridge
• Region: East of England › East Anglia › Cambridgeshire CC
• Activity type: Research Organisations
• Administrative Contact: Carol Lyon (Ms.)
• Total cost: No data

KRAEFTENS BEKAEMPELSE

Denmark

• EU contribution: € 519 662,80
• Address: STRANDBOULEVARDEN 49 ; 2100 Koebenhavn
• Region: Danmark › Hovedstaden › Byen København
• Activity type: Research Organisations
• Administrative Contact: Claus Skytte Rasmussen (Mr.)
• Total cost: No data

BREAST INTERNATIONAL GROUP - AISBL

Belgium

• EU contribution: € 42 882,30
• Address: BOULEVARD DE WATERLOO 121 ; 1000 BRUXELLES
• Activity type: Research Organisations
• Administrative Contact: Livia Meirsman (Ms.)
• Total cost: No data

INSTITUTE OF CANCER RESEARCH: THE ROYAL CANCER HOSPITAL LBG

United Kingdom

• EU contribution: € 600 674,80
• Address: OLD BROMPTON ROAD 123 ; SW7 3RP London
• Region: London › Inner London — West › Kensington & Chelsea and Hammersmith & Fulham
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Donna Conway (Ms.)
• Total cost: No data

CENTRE DE LUTTE CONTRE LE CANCER LEON BERARD

France

• EU contribution: € 136 884,00
• Address: RUE LAENNEC 28 ; 69373 Lyon
• Region: Auvergne-Rhône-Alpes › Rhône-Alpes › Rhône
• Activity type: Research Organisations
• Administrative Contact: Marina Rousseau-Tsangiris (Dr.)
• Total cost: No data

UNIVERSITY COLLEGE LONDON

• EU contribution: € 170 906,40
• Address: GOWER STREET ; WC1E 6BT LONDON
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Greta Borg-Carbott (Ms.)
• Total cost: No data

CANCER COUNCIL VICTORIA

Australia

• EU contribution: No data
• Address: 615 ST KILDA ROAD ; 3004 Melbourne Victoria
• Activity type: Research Organisations
• Administrative Contact: Priscilla Hinds (Ms.)
• Total cost: No data

UNIVERSITY OF WARWICK

United Kingdom

• EU contribution: € 319 872,00
• Address: KIRBY CORNER ROAD UNIVERSITY HOUSE ; CV4 8UW COVENTRY
• Region: West Midlands (England) › West Midlands › Coventry
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Peter Hedges (Dr.)
• Total cost: No data