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Cultivated Adult Stem Cells as Alternative for Damaged tissue

Objective

Rapid progress in stem cell research pave the way for the development and use of new cell therapy products in regenerative medicine. The objective of CASCADE is to provide the European Community with unique expertise which focuses on the GMP production of mesenchymal stem cells (MSC) and their use in treating skin and corneal wounds, so that quality and safety criteria are paramount and match therapeutic expectations. Commencing with known procedures, CASCADE will develop innovative technologies based on the expertise of its partners. Among our research themes, the specific issue of multiple recipients and universal donors will be investigated. To this end, human MSC will be derived from 4 tissues, bone marrow, fat tissue, cord blood and amniotic membrane, according to good manufacturing practice (GMP). Phenotypic identity of GMP produced MSC, their genetic status and their potential for transformation will constitute the basis for establishing standards for controlling cell production. The efficacy of GMP produced MSC will be tested in in vitro and in vivo models, and the immunological consequences of their use will be studied. Moreover, during the whole CASCADE initiative, ethical and legal issues raised as a result of MSC therapies will be considered. Direct collaboration with two clinical networks will allow CASCADE to finely tune production specifications, and define optimal clinical protocols for these MSC-based cellular therapies. CASCADE will therefore gather together leading European cell therapy laboratories with unrivalled expertise in the production of therapeutic cells and in MSC biology, four SMEs with specific know-how in GMP production of cells and two clinical networks in dermatology and ophthalmology. The outcome will be a consortium that encompasses all the technologies and skills required to efficiently develop innovative technologies for the production of clinical grade MSC and to translate this production into a cell drug to repair wounds.

Field of science

  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /medical and health sciences/clinical medicine/ophthalmology
  • /medical and health sciences/clinical medicine/dermatology

Call for proposal

FP7-HEALTH-2007-B
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

ETABLISSEMENT FRANCAIS DU SANG
Address
Avenue Du Stade De France 20
93210 La Plaine Saint Denis
France
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
EU contribution
€ 430 000
Administrative Contact
Laurent Beauverger (Mr.)

Participants (15)

DRK-BLUTSPENDEDIENST BADEN-WURTTEMBERG-HESSEN GGMBH
Germany
EU contribution
€ 599 414
Address
Friedrich Ebert Strasse 107
68167 Mannheim
Activity type
Research Organisations
Administrative Contact
Hubert Schrezenmeier (Prof.)
FONDAZIONE IRCCS CA' GRANDA - OSPEDALE MAGGIORE POLICLINICO
Italy
EU contribution
€ 204 578
Address
Via Francesco Sforza 28
20122 Milano
Activity type
Other
Administrative Contact
Rosaria Giordano (Dr.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 243 725
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Annick Bertault (Ms.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 115 243
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
Administrative Contact
Armelle Barelli (Ms.)
UNIVERSITA DEGLI STUDI DI VERONA
Italy
EU contribution
€ 152 800
Address
Via Dell Artigliere 8
37129 Verona
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mauro Krampera (Dr.)
UNIVERSITATEA DE MEDICINA SI FARMACIE VICTOR BABES TIMISOARA
Romania
EU contribution
€ 132 000
Address
Piata Eftimie Murgu 2A
300041 Timisoara
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Constanta Caplar (Ms.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 143 000
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Samantha Hatzis (Ms.)
THE UNIVERSITY OF SHEFFIELD
United Kingdom
EU contribution
€ 80 000
Address
Firth Court Western Bank
S10 2TN Sheffield
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gill Wells (Ms.)
ABCELL-BIO Sarl
France
EU contribution
€ 135 000
Address
Rue Taitbout 85
75009 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jean-Pierre Mouscadet (Mr.)
ORGANES TISSUS REGENERATION REPARATION REMPLACEMENT
France
EU contribution
€ 74 999
Address
Rue Francaise 4
75001 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Denis Barritault (Prof.)
BIOTRACK SRL
Italy
EU contribution
€ 120 249
Address
Via Einstein 1
26900 Lodi
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Elisa Filippi (Dr.)
UNIVERSITAT DES SAARLANDES
Germany
EU contribution
€ 123 000
Address
Campus
66123 Saarbrucken
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mareike Schmitt (Ms.)
UNIVERSITAET ULM
Germany
EU contribution
€ 142 798
Address
Helmholtzstrasse 16
89081 Ulm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Frank Gleixner (Mr.)
UNIVERSITATSKLINIKUM HEIDELBERG
Germany
EU contribution
€ 83 000
Address
Im Neuenheimer Feld 672
69120 Heidelberg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Thorsten Brietz
ALCIMED
France
EU contribution
€ 199 861
Address
Boulevard De Montmorency 57
75016 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
David Bariau (Mr.)