Skip to main content

Large-scale, high-throughput automated systems for phenotyping mouse models of human disease

Objective

We are now entering an era of genomic exploration. The mouse is a pre-eminent model not only to map all mammalian genes, but to determine the function of each of these genes. There are now many large-scale projects to create collections of mutant and knock-out mice. However the next step which will add immense value to these collections will be the determination of the phenotype of each of these models. This will be an immense effort and will require input from laboratories and mouse phenotyping centres across the world. For the phenotype to be comparable across strains and between centres, it needs to be determined using standard protocols or SOPs, such as those contained in the European Mouse Phenotyping Resource of Standardised Screens (EMPReSS - www.empress.har.mrc.ac.uk). The goal of PhenoScale is to automate phenotyping in large-scale phenotyping using EMPReSS protocols; with the aim of adding economies of scale, enhancing automated data capture and increasing throughput. The technical development within the project is lead by the SME, TSE Systems GmbH, who will work with some of the leading mouse phenotyping centres in Europe at MRC, UK, CNR, Italy and GSF, Germany. The objectives are: 1) High-throughput Phenotyping: a) Development of a new high-throughput automated phenotyping platform PSS009 using home cage monitoring. 2) Development of new EMPReSS SOPs using PSS009 and validation of this approach with selected mouse models at different sites / European mouse clinics (cross-checking / cross-validation). 3) Optimization of the high-throughput technology systems by advanced interfacing and extended software capabilities. 4) Promotion of the new high-throughput systems and novel established SOPs to other phenotyping centres.

Field of science

  • /natural sciences/computer and information sciences/software

Call for proposal

FP7-HEALTH-2007-B
See other projects for this call

Funding Scheme

CP-TP - Collaborative Project targeted to a special group (such as SMEs)

Coordinator

MEDICAL RESEARCH COUNCIL
Address
North Star Avenue Polaris House 2 Floor David Phillips Building
SN2 1FL Swindon
United Kingdom
Activity type
Research Organisations
EU contribution
€ 775 541
Administrative Contact
Hilary Gates (Dr.)

Participants (4)

TSE SYSTEMS GMBH
Germany
EU contribution
€ 1 200 025
Address
Siemenstrasse 21
61352 Bad Homburg Vor Der Hohe
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Hans-Peter Engler (Dr.)
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 499 500
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations
Administrative Contact
Glauco Pasquale Tocchini-Valentini (Prof.)
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany
EU contribution
€ 499 998
Address
Ingolstadter Landstrasse 1
85764 Neuherberg
Activity type
Research Organisations
Administrative Contact
Juergen Ertel (Dr.)
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
Italy
EU contribution
€ 24 397
Address
Via Morego 30
16163 Genova
Activity type
Research Organisations
Administrative Contact
Gabriele Ballero (Mr.)