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Genomic approaches to metabolite exploitation from Xenorhabdus, Photorhabdus

Objective

The majority of compounds used to treat diseases come from a single group of organisms, the actinomycetes. This over-reliance on a single organism to produce the worlds drugs is a major problem for the development of compounds with alternative modes of action which can overcome and delay the onset of drug resistance. To address this problem we will form an international multi-disciplinary group of experts to bioprospect for biologically active natural products. The central aim of this programme is to start rapidly deriving novel drugs from non-actinomycete sources. We will isolate novel strains of the proven but not well-explored drug producers Xenorhabdus and Photorhabdus. These bacteria will be isolated from insect pathogenic nematodes and characterized taxonomically (WP1) and strains will be analyzed for the production of novel compounds (WP2). This library of compounds will then be tested against a broad set of targets including bacteria, fungi, protozoans, nematodes, insects, and mammalian cell cultures (WP3). The five most productive bacterial strains will then be fully sequenced and used to construct genomic libraries. These libraries will be used to generate recombinant clones in heterologous hosts, enabling fast and efficient biotechnological production of the bioactive compounds (WP4). To ensure efficient interactions and comparability of results, especially regarding the bioactivity data, training sessions will be organized with seminars and hands on experience for each of the groups at a central site (WP5). Robust patent stuctures will ensure efficient technology transfer to our industrial partners (WP6) and overall coordination of the scientific and training programs will be overseen by WP7.

Field of science

  • /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance
  • /natural sciences/biological sciences/microbiology/mycology
  • /natural sciences/biological sciences/microbiology/mycology/ethnomycology

Call for proposal

FP7-HEALTH-2007-B
See other projects for this call

Funding Scheme

CP-SICA - Collaborative project for specific cooperation actions dedicated to international cooperation partner countries (SICA)

Coordinator

JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN
Address
Theodor W Adorno Platz 1
60323 Frankfurt Am Main
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 700 400
Administrative Contact
Helge Bode (Prof.)

Participants (5)

INSTITUTE OF ECOLOGY AND BIOLOGICAL RESOURCES VIETNAMESE ACADEMY OF SCIENCE AND TECHNOLOGY
Vietnam
EU contribution
€ 115 200
Address
Hoang Quoc Viet, Nghiado 18
10000 Hanoi
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ke Long Phan (Dr.)
MAHIDOL UNIVERSITY
Thailand
EU contribution
€ 139 760
Address
Ratchawithi Road 420/6
10400 Bangkok
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Porntip Petmitr (Dr.)
UNIVERSITY OF BATH
United Kingdom
EU contribution
€ 656 400
Address
Claverton Down
BA2 7AY Bath
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Peter Hompstead (Mr.)
THE UNIVERSITY OF EXETER
United Kingdom
EU contribution
€ 682 200
Address
The Queen's Drive Northcote House
EX4 4QJ Exeter
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Enda Clarke (Dr.)
EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH
Germany
EU contribution
€ 395 200
Address
Heinrich-hertz-allee 1
66386 St Ingbert
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Vera Siegmund (Dr.)