Objective The majority of compounds used to treat diseases come from a single group of organisms, the actinomycetes. This over-reliance on a single organism to produce the worlds drugs is a major problem for the development of compounds with alternative modes of action which can overcome and delay the onset of drug resistance. To address this problem we will form an international multi-disciplinary group of experts to bioprospect for biologically active natural products. The central aim of this programme is to start rapidly deriving novel drugs from non-actinomycete sources. We will isolate novel strains of the proven but not well-explored drug producers Xenorhabdus and Photorhabdus. These bacteria will be isolated from insect pathogenic nematodes and characterized taxonomically (WP1) and strains will be analyzed for the production of novel compounds (WP2). This library of compounds will then be tested against a broad set of targets including bacteria, fungi, protozoans, nematodes, insects, and mammalian cell cultures (WP3). The five most productive bacterial strains will then be fully sequenced and used to construct genomic libraries. These libraries will be used to generate recombinant clones in heterologous hosts, enabling fast and efficient biotechnological production of the bioactive compounds (WP4). To ensure efficient interactions and comparability of results, especially regarding the bioactivity data, training sessions will be organized with seminars and hands on experience for each of the groups at a central site (WP5). Robust patent stuctures will ensure efficient technology transfer to our industrial partners (WP6) and overall coordination of the scientific and training programs will be overseen by WP7. Fields of science natural sciencesbiological sciencesgeneticsnatural sciencesbiological sciencesmicrobiologybacteriologynatural sciencesbiological sciencesmicrobiologymycologymedical and health sciencesbasic medicinepharmacology and pharmacydrug resistancenatural sciencesbiological scienceszoologyentomology Keywords Photorhabdus Xenorhabdus drug discovery exploitation multiple-target bioactivity testing Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2007-2.3.4-3 - Bioprospecting for drug leads Call for proposal FP7-HEALTH-2007-B See other projects for this call Funding Scheme CP-SICA - Collaborative project for specific cooperation actions dedicated to international cooperation partner countries (SICA) Coordinator JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN EU contribution € 700 400,00 Address THEODOR W ADORNO PLATZ 1 60323 Frankfurt Am Main Germany See on map Region Hessen Darmstadt Frankfurt am Main, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Helge Bode (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all INSTITUTE OF ECOLOGY AND BIOLOGICAL RESOURCES VIETNAMESE ACADEMY OF SCIENCE AND TECHNOLOGY Vietnam EU contribution € 115 200,00 Address HOANG QUOC VIET, NGHIADO 18 10000 HANOI See on map Activity type Higher or Secondary Education Establishments Administrative Contact Ke Long Phan (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MAHIDOL UNIVERSITY Thailand EU contribution € 139 760,00 Address RATCHAWITHI ROAD 420/6 10400 Bangkok See on map Activity type Higher or Secondary Education Establishments Administrative Contact Porntip Petmitr (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY OF BATH United Kingdom EU contribution € 656 400,00 Address CLAVERTON DOWN BA2 7AY Bath See on map Region South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bath and North East Somerset, North Somerset and South Gloucestershire Activity type Higher or Secondary Education Establishments Administrative Contact Peter Hompstead (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE UNIVERSITY OF EXETER United Kingdom EU contribution € 682 200,00 Address THE QUEEN'S DRIVE NORTHCOTE HOUSE EX4 4QJ Exeter See on map Region South West (England) Devon Devon CC Activity type Higher or Secondary Education Establishments Administrative Contact Enda Clarke (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH Germany EU contribution € 395 200,00 Address HEINRICH-HERTZ-ALLEE 1 66386 St Ingbert See on map Region Saarland Saarland Saarpfalz-Kreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Vera Siegmund (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data