Skip to main content

Population biology and molecular genetics of vectorial capacity in Anopheles gambiae: targeting reproductive behaviour and immunity for transmission-refractory interventions

Objective

Malaria, one of the world’s most devastating diseases, is caused by protozoan parasites of the genus Plasmodium and is obligatory transmitted to humans by anopheline mosquitoes. The African mosquito species Anopheles gambiae s.s., is the major vector of this disease. Research groups from 3 European countries and 3 African teams will integrate their resources and scientific expertise in malaria research to expand knowledge of mosquito biology and of vector-parasite interactions, exploiting the opportunities provided by the recently available genome information and technological developments for mosquito vectors. The joint scientific program of the MALVECBLOK Consortium integrates for the first time three crucial aspects of biology of An. gambiae: reproduction, immunity and population biology, with the aim to ultimately provide novel concepts and targets for malaria control. The main objectives will address: (i) The molecular bases of reproductive biology of the mosquito vector, and its effects on immunity and Plasmodium transmission; (ii) The molecular mechanisms which determine the mosquito immune status and regulate Plasmodium sporogony and transmission, in both laboratory settings and natural populations; (iii) The role of genetic polymorphism in genes controlling reproduction and immunity on structure of mosquito populations and malaria transmission in Africa. In order to reach these objectives, MALVECBLOK will employ a number of concerted strategies in support of its 3-year agenda. Special attention will be given to cutting-edge training opportunities and sharing of resources, by implementing interactive programmes for the training and exchange of personnel at all levels, and by rationalising and coordinating investment. The innovative knowledge generated under this trans-disciplinary project will promote European scientific competitiveness and will impact global health issues.

Field of science

  • /medical and health sciences/health sciences/infectious disease/malaria
  • /natural sciences/biological sciences/genetics and heredity
  • /natural sciences/biological sciences/reproductive biology
  • /natural sciences/biological sciences/molecular biology/molecular genetics

Call for proposal

FP7-HEALTH-2007-B
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Address
Rue Michel Ange 3
75794 Paris
France
Activity type
Research Organisations
EU contribution
€ 599 029
Administrative Contact
Bertrand Minault (Mr.)

Participants (6)

STICHTING KATHOLIEKE UNIVERSITEIT
Netherlands
EU contribution
€ 418 491
Address
Geert Grooteplein Noord 9
6525 EZ Nijmegen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Wim Bruinenberg (Mr.)
UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
Italy
EU contribution
€ 314 316
Address
Piazzale Aldo Moro 5
00185 Roma
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Aldo Liccardi (Dr.)
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT
France
EU contribution
€ 314 310
Address
Boulevard De Dunkerque 44 Cs 90009
13572 Marseille
Activity type
Research Organisations
Administrative Contact
Ariel Crozon (Ms.)
UNIVERSITE DE BAMAKO
Mali
EU contribution
€ 105 000
Address
Campus Universitaire De Badalabougou
Bamako
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Job Amagoin Tessougue (Mr.)
THE INTERNATIONAL CENTRE OF INSECT PHYSIOLOGY AND ECOLOGY LBG
Kenya
EU contribution
€ 105 000
Address
Off Thika Road Duduville Campus
0100 Nairobi
Activity type
Research Organisations
Administrative Contact
Christian Borgemeister (Prof.)
UNIVERSITA DEGLI STUDI DI PERUGIA
Italy
EU contribution
€ 446 354
Address
Piazza Dell Universita 1
06123 Perugia
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rosario Donato (Prof.)