Project description Virtual Physiological Human Show the project objective Hide the project objective The ContraCancrum i.e. the Clinically Oriented Translational Cancer Multilevel Modelling project aims at developing a composite multilevel platform for simulating malignant tumour development and tumour and normal tissue response to therapeutic modalities and treatment schedules. The project aims at having an impact primarily in (a) the better understanding of the natural phenomenon of cancer at different levels of biocomplexity and most importantly (b) the disease treatment optimization procedure in the patient's individualized context by simulating the response to various therapeutic regimens. The predictions of the simulators to be developed will rely on the imaging, histopathological, molecular and clinical data of the patient. Fundamental biological mechanisms involved in tumour development and tumour and normal tissue treatment response such as metabolism, cell cycle, tissue mechanics, cell survival following treatment etc. will be modelled. Stem cells will be addressed in the context of both tumour and normal tissue behaviour. From the mathematical point of view the simulators will exploit several discrete and continuous mathematics methods such as cellular automata, the generic Monte Carlo technique, finite elements, differential equations, novel dedicated algorithms etc. A study of the analogies of tumour growth with embryological development is expected to provide insights into both mechanisms. ContraCancrum will deploy two important clinical studies for validating the models, one on lung cancer and one on gliomas. The crucial validation work will be based on comparing the multi-level therapy simulation predictions with the actual medical data (including medical images), acquired before and after therapy. ContraCancrum aims to pave the way for translating clinically validated multilevel cancer models into clinical practice. Fields of science medical and health sciencesclinical medicineoncologylung cancernatural sciencesmathematicspure mathematicsmathematical analysisdifferential equationsmedical and health sciencesmedical biotechnologycells technologiesstem cells Programme(s) FP7-ICT - Specific Programme "Cooperation": Information and communication technologies Topic(s) ICT-2007.5.3 - Virtual physiological human Call for proposal FP7-ICT-2007-2 See other projects for this call Funding Scheme CP - Collaborative project (generic) Coordinator IDRYMA TECHNOLOGIAS KAI EREVNAS Address N plastira str 100 70013 Irakleio Greece See on map Region Νησιά Αιγαίου Κρήτη Ηράκλειο Activity type Research Organisations Administrative Contact Zinovia Papatheodorou (Ms.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 543 970,00 Participants (7) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITAET BERN Switzerland EU contribution € 454 000,00 Address Hochschulstrasse 6 3012 Bern See on map Region Schweiz/Suisse/Svizzera Espace Mittelland Bern / Berne Activity type Higher or Secondary Education Establishments Administrative Contact Philippe Büchler (Dr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERZITA KARLOVA Czechia EU contribution € 122 360,00 Address Ovocny trh 560/5 116 36 Praha 1 See on map Region Česko Praha Hlavní město Praha Activity type Higher or Secondary Education Establishments Administrative Contact Milena Stiborová (Dr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITAT DES SAARLANDES Germany EU contribution € 688 400,00 Address Campus 66123 Saarbrucken See on map Region Saarland Saarland Regionalverband Saarbrücken Activity type Higher or Secondary Education Establishments Administrative Contact Corinna Hahn (Ms.) Links Contact the organisation Opens in new window Website Opens in new window PHILIPS TECHNOLOGIE GMBH Germany EU contribution € 415 107,00 Address Luebeckertordamm 5 20099 Hamburg See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Siegfried Lindau (Mr.) Links Contact the organisation Opens in new window Website Opens in new window EREVNITIKO PANEPISTIMIAKO INSTITOUTO SYSTIMATON EPIKOINONION KAI YPOLOGISTON Greece EU contribution € 531 000,00 Address Patision 42 106 82 Athina See on map Region Αττική Aττική Κεντρικός Τομέας Αθηνών Activity type Research Organisations Administrative Contact Georgios Stamatakos (Dr.) Links Contact the organisation Opens in new window Website Opens in new window UCL Elizabeth Garrett Anderson Institute for Women’s Health United Kingdom EU contribution € 675 400,00 Address Gower street WC1E 6BT London See on map Region London Inner London — West Camden and City of London Activity type Higher or Secondary Education Establishments Administrative Contact Michael Browne (Mr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITY OF BEDFORDSHIRE United Kingdom EU contribution € 356 320,00 Address University square LU1 3JU Luton See on map Region East of England Bedfordshire and Hertfordshire Luton Activity type Higher or Secondary Education Establishments Administrative Contact Angus Duncan (Prof.) Links Contact the organisation Opens in new window Website Opens in new window
