Project description
Virtual Physiological Human
Cardiovascular disease (CVD) has a significant impact on the European society in terms of mortality, morbidity and allied healthcare costs. The opportunity of multi-scale modelling spanning, sub-cellular level up to whole heart is to improve CVD outcomes by providing a consistent, biophysically-based framework for the integration of the huge amount of fragmented and inhomogeneous data currently available. However, multi-scale models have not yet been translated into clinical environments mainly due to the difficulty of personalising biophysical models. The challenge of the euHeart project is to directly address this need by combining novel ICT technologies with integrative multi-scale computational models of the heart in clinical environments to improve diagnosis, treatment planning and interventions for CVD.
To meet this challenge we will bring together leading European physiological modelling and cardiac groups to develop, integrate and clinically validate patient-specific computational models of the cardiac physiology and disease-related processes. The main outcome of euHeart will be an open source framework for the description and representation of normal and pathological multi-scale and multi-physics cardiovascular models, using the international encoding standards. In addition, a library of innovative tools for the execution of the biophysical simulations, the personalisation of the models and the automated analysis of multi-modal images are developed.
Evidence of clinical benefit will be collected to quantify potential impact for a number of significant CVD's namely, heart failure, cardiac rhythm disorder, coronary artery disease and valvular and aortic diseases. Each of the selected clinical applications provides a complementary focus for the resulting integrated model of cardiac fluid-electro-mechanical function. The consortium contains a mix of academic leadership, clinical sites, and industrial partners ensuring exploitation of the wealth of models
Fields of science
Call for proposal
FP7-ICT-2007-2
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Funding Scheme
CP - Collaborative project (generic)Coordinator
20099 HAMBURG
Germany
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Participants (20)
1930 ZAVENTEM
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76131 Karlsruhe
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69120 Heidelberg
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76131 KARLSRUHE
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64404 BICKENBACH
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69120 Heidelberg
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12247 BERLIN
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28046 MADRID
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28040 MADRID
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28050 Madrid
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08002 Barcelona
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75654 Paris
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78153 Le Chesnay Cedex
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1105AZ Amsterdam
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5684 PC Best
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5611 ZS Eindhoven
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OX1 2JD Oxford
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WC2R 2LS London
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S10 2TN Sheffield
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35065 RENNES CEDEX
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