Sarcomeric-Simulation AppRoach in a COmputational Multiscale EnviRonmEnt

Project Information

S-SARCOMERE

Grant agreement ID: 224896

Project closed

Start date 1 January 2009

End date 31 December 2011

Funded under

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Total cost € 45 000,00

EU contribution € 45 000,00

Coordinated by

UNIVERSITY COLLEGE LONDON

Objective

First, a simulation environment of the sarcomere will be developed by using lumped parameter models. This model will be incorporated into existing models of the cardiac contraction to eventually build a multi-scale model of the cardiovascular loop. At a later stage, this model will be coupled to local 3D models of cardiac devices. The study will focus on one specific application in cardiovascular engineering: valve closure force. Whilst forces of closure of prosthetic heart valves are an important characteristic with respect to the design, they are very difficult to quantify. Also, cavitation might be a problem, as could lead to catastrophic failure or blood damage. Closure lasts for only about 35 ms, and there are no adequate models that can predict or quantify the effect of local/cellular events of chemical, biochemical or mechano-electrical nature at the ventricular level on the closure forces. For potentially high-risk patients is possible that pharmacokinetical intervention may reduce the cavitation potential of the valve and risk of fracture. We propose to develop the first coherent multi-scale model of the system taking into account the cellular mechanisms of cardiac contraction, with feedback between electrochemical events in the vessel wall and detail haemodynamic characteristics of the flow

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

• medical and health sciences › medical biotechnology › implants

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Keywords

• Biomedical engineering
• Biophysics
• Computational biology
• Medical physics
• Simulation engineering

Programme(s)

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Topic(s)

• PEOPLE-2007-2-2.ERG - Marie Curie Action: "European Reintegration Grants"

Call for proposal

FP7-PEOPLE-2007-2-2-ERG
See other projects for this call

Funding Scheme

MC-ERG - European Re-integration Grants (ERG)

Coordinator

UNIVERSITY COLLEGE LONDON

• EU contribution: € 45 000,00
• Address: GOWER STREET ; WC1E 6BT LONDON ;
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data