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The development, validation and implementation of human systemic Toxic Equivalencies (TEQs) as biomarkers for dioxin-like compounds

Objective

Chlorinated dioxins and biphenyls (PCBs) commonly occur in the human food chain and can still be detected at levels that might cause long term health effects. Exposure to dioxin-like compounds involves a complex mixture with a common mechanism of action involving endocrine, developmental, carcinogenic, immuno and neurological effects. Risk assessment is done with an additive model for mixture toxicity. Based on this the Toxic Equivalency (TEQ) concept was developed as a biomarker for exposure and risk. TEQs are the sum of congener-specific toxic equivalency factors (TEFs) multiplied by the concentration in a matrix, e.g. blood. TEF values are a composite quantitative value from a range of biomarkers that are congener and endpoint specific. Present human TEQs have been derived from oral administration experiments providing ‘intake’ TEFs. Regulatory authorities frequently use ‘intake’ TEQs for blood and tissues considering it a biomarker for exposure or effect. Experimental evidence shows that using ‘uptake’ TEQs as ‘systemic’ biomarkers may lead to misinterpretation of risks. Therefore, development and validation of ‘systemic’ TEFs and TEQs as biomarkers is necessary. Major objectives of SYSTEQ are: i) establish ‘systemic’ TEFs and TEQs, ii) identify novel quantifiable biomarkers with newest molecular methods, e.g. genetic fingerprinting profiles, iii) extra focus on effects in peripheral lymphocytes as biomarkers, iv) identify differences between humans and experimental species. The ‘systemic’ TEFs and TEQs from SYSTEQ will be used in conjunction with results of the completed EU PCBRISK project, in which two populations from Slovakia with very different exposure were studied. Individual blood levels and different biomarkers are already available. Results of SYSTEQ are also going to be used to establish international consensus values of ‘systemic’ TEFs at WHO level, facilitating the global use of ‘systemic’ TEQs as biomarkers of effect and exposure.

Call for proposal

FP7-ENV-2008-1
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Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

UNIVERSITEIT UTRECHT
Address
Heidelberglaan 8
3584 CS Utrecht
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 864 141
Administrative Contact
Monique Van Der Hoek (Ms.)

Participants (5)

UMEA UNIVERSITET
Sweden
EU contribution
€ 499 800
Address
Universitetomradet
901 87 Umea
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Patrik Anderson (Dr.)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 498 600
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Riitta Ljungstrom (Ms.)
TECHNISCHE UNIVERSITAT KAISERSLAUTERN
Germany
EU contribution
€ 474 295,70
Address
Gottlieb Daimler Strasse
67663 Kaiserslautern
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Berthold Klein (Mr.)
VYZKUMNY USTAV VETERINARNIHO LEKARSTVI
Czechia
EU contribution
€ 318 759,56
Address
Hudcova 296/70
621 00 Brno
Activity type
Other
Administrative Contact
Marketa Kabourkova (Ms.)
SLOVENSKA ZDRAVOTNICKA UNIVERZITA V BRATISLAVE
Slovakia
EU contribution
€ 48 000
Address
Limbova 12
83303 Bratislava
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Milan Cagan (Mr.)