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Plant Production of Vaccines

Objectif

Advances in the technologies for expressing proteins and extracting them from plants have allowed several plant-made products to be assessed for safety and efficacy. The results have been favourable and have culminated in the demonstration that plant-produced vaccine can protect target animals against challenge. However, most of these successes have concerned the production of antigens which had previously been produced using established methods such as mammalian cell culture. For plants to fulfil their potential as a means of producing vaccines, it is now imperative that methods are developed for the rapid production and characterisation of a large number of vaccine candidates. This project will exploit recent developments in transient expression technologies to screen a range of vaccine candidates in plants. These methods can produce milligram quantities of candidate proteins in a matter of days using only small amounts (tens of grams) of plant tissue. The project will concentrate on screening vaccine candidate proteins which are capable of forming virus-like particles (VLPs), as such particulate structures are known to be potent stimulators of the immune system. Furthermore, they can be used as carriers of additional immunogenic sequences for the developments of novel vaccines. The project will focus on diseases which are particularly relevant to both the EU and Russia, including Avian Influenza virus (AIV), Blue Tongue Virus (BTV) Porcine Respiratory and Reproductive Syndrome Virus (PRRSV). The ability to screen many candidate VLPs will result in the development of novel vaccines against these and other important pathogens. At the same time as the screening is carried out, methods will be developed to allow the rapid translation of the information gained through the transient studies into larger scale production systems for the most promising candidates. This will enable low cost vaccines to be developed for use for livestock and, ultimately, humans.

Appel à propositions

FP7-KBBE-2008-2B
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Coordinateur

JOHN INNES CENTRE
Adresse
Norwich Research Park Colney
NR4 7UH Norwich
United Kingdom
Type d’activité
Research Organisations
Contribution de l’UE
€ 474 110
Contact administratif
Mary Anderson (Dr.)

Participants (10)

SCOTTISH CROP RESEARCH INSTITUTE
United Kingdom
Contribution de l’UE
€ 306 233
Adresse
Invergowrie
DD2 5DA Dundee
Type d’activité
Research Organisations
Contact administratif
Neil Hattersley (Dr.)
WAGENINGEN UNIVERSITY
Pays-Bas
Contribution de l’UE
€ 276 454
Adresse
Droevendaalsesteeg 4
6708 PB Wageningen
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Rudie Jullens (Mr.)
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Espagne
Contribution de l’UE
€ 292 187
Adresse
Calle Serrano 117
28006 Madrid
Type d’activité
Research Organisations
Contact administratif
Carlos Manuel Abad Ruiz (Mr.)
CONSIGLIO NAZIONALE DELLE RICERCHE
Italie
Contribution de l’UE
€ 163 432
Adresse
Piazzale Aldo Moro 7
00185 Roma
Type d’activité
Research Organisations
Contact administratif
Concetta Mottura (Ms.)
PLOVDIVSKI UNIVERSITET PAISIY HILENDARSKI
Bulgarie
Contribution de l’UE
€ 155 650
Adresse
24 Tzar Asen
4000 Plovdiv
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Valentina Toneva (Prof.)
UNIVERSITY OF CAPE TOWN
Afrique du Sud
Contribution de l’UE
€ 230 288
Adresse
Private Bag X3
7701 Rondebosch
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Sue Custers (Ms.)
Centre Bioengineering of the Russian academy of sciences
Russie
Contribution de l’UE
€ 100 000
Adresse
Prosp. 60-Let Oktiabria 7-1
117312 Moscow
Type d’activité
Research Organisations
Contact administratif
Nikolay Ravin (Prof.)
M V LOMONOSOV MOSCOW STATE UNIVERSITY
Russie
Adresse
Leninskie Gory Main Building
119992 Moscow
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Joseph Atabekov (Prof.)
SMORODINTSEV RESEARCH INSTITUTE OF INFLUENZA OF THE MINISTRY OF HEALTH OF THE RUSSIAN FEDERATION
Russie
Adresse
Professora Popova Street 15/17
197376 St Petersburg
Type d’activité
Research Organisations
Contact administratif
Liudmila Tsybalova (Dr.)
FGI FEDERAL CENTRE FOR ANIMAL HEALTH
Russie
Adresse
Jur Evets
600901 Vladimir
Type d’activité
Research Organisations
Contact administratif
Vladimir Borisov (Dr.)