Skip to main content

Plant Terpenoids for Human Health: a chemical and genomic approach to identify and produce bioactive compounds

Objective

Plant secondary metabolites are an important source of therapeutic drugs or drug leads. The advent of genomic and metabolomic technologies has now made it possible to bring the field of plant natural products into the 21st century and replace serendipitous and haphazard finding by rational design and discovery. This proposal is devoted to plant terpenes, the largest and most diverse group of plant natural products. TERPMED will focus on sesquiterpene lactones and phenolic diterpenes because of the presence of distinct functional groups and their high potential as novel human drugs for treating cancer and neurological disorders. By using a combination of comparative metabolomics and genomics, significant advances will be achieved in the understanding of the biosynthetic pathways of these compounds. Focusing on specific functional groups such as γ-butyrolactones and phenolics amongst the terpenes will allow the development of high-throughput analytical methodologies to detect, purify and characterize compounds bearing these groups. A comprehensive library of these compounds within a subset of plant biodiversity will be established. The compounds isolated will be tested for biological activity and the most active molecules will be selected. High throughput cDNA sequencing coupled to the comparative analysis of the metabolic profiles of targeted species will be achieved for the elucidation of the biosynthetic pathways of these compounds. Innovative production platforms using plant secretory organs such as the trichomes will be tested for the pilot production of the most promising compounds identified and the production of novel compounds by combinatorial biosynthesis.

Call for proposal

FP7-KBBE-2008-2B
See other projects for this call

Coordinator

UNIVERSITAT DE BARCELONA
Address
Gran Via De Les Corts Catalanes 585
08007 Barcelona
Spain
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 537 091,17
Administrative Contact
Albert Ferrer (Dr.)

Participants (7)

WAGENINGEN UNIVERSITY
Netherlands
EU contribution
€ 475 086,25
Address
Droevendaalsesteeg 4
6708 PB Wageningen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Harro Bouwmeester (Prof.)
Prisna b.v.
Netherlands
EU contribution
€ 211 433,21
Address
Rijnkade 17A
1382GS Weesp
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Christof Kersch (Dr.)
INSTITUT ZA BIOLOSKA ISTRAZIVANJA
Serbia
EU contribution
€ 368 508,80
Address
Bulevar Despota Stefana 142
11060 Beograd
Activity type
Research Organisations
Administrative Contact
Milica Djordjevic (Ms.)
ARISTOTELIO PANEPISTIMIO THESSALONIKIS
Greece
EU contribution
€ 386 150
Address
Kedea Building, Tritis Septemvriou, Aristotle Univ Campus
54636 Thessaloniki
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christina Besta (Ms.)
THE BOARD OF REGENTS OF THE UNIVERSITY OF WISCONSIN SYSTEM
United States
Address
Linden Drive 1220 Vanhise Hall 1860
53706 Madison Wi
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jeffrey A. Johnson (Prof.)
STICHTING WAGENINGEN RESEARCH
Netherlands
EU contribution
€ 514 548,21
Address
Droevendaalsesteeg 4
6708 PB Wageningen
Activity type
Research Organisations
Administrative Contact
Leny Versteeg (Ms.)
LEIBNIZ-INSTITUT FUR PFLANZENBIOCHEMIE
Germany
EU contribution
€ 201 600,36
Address
Weinberg 3
06120 Halle
Activity type
Research Organisations
Administrative Contact
Lothar Franzen (Mr.)