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MAGNETIC NANOCONTAINERS FOR COMBINED HYPERTHERMIA AND CONTROLLED DRUG RELEASE

Objetivo

The aim of this project is the assembly and the fabrication of a new generation of multifunctional nanostructures for performing combined hyperthermia and controlled drug release, specifically targeted to cancer cells. The “magnetic nanocontainers” we intend to develop can perform at the same time cell recognition, hyperthermia treatment, and, as a consequence of the heat and /or cell environment stimuli, the release of drug with high selectivity for ovarian carcinoma. These multifunctional tasks are made possible due to the inclusion of three main components: a) the magnetic nanoparticles, allowing detection by MRI, cancer treatment by hyperthermia and providing stimuli for drug release; b) the nanocontainers, which allow for drug encapsulation and protection from degradation, facilitate the release of the drug upon application of an external stimulus, such as heat, or an internal one, such as the acidic pH of the tumour cells; c) the antibody fragments attached to the surface of the magnetic nanocontainers to deliver them selectively to the ovarian cancer cells. The individual building blocks and their assemblies will be characterized with respect to physical, chemical, and biological features, followed by dissemination of the newly acquired knowledge. Cell culture experiments will allow to understand the performance of such nano-tools in vitro. Directed towards application in patients, in vivo animal studies will be carried out on the most successful magnetic nanocontainers. The objectives of this proposal cover a wide range of scientific fields, hence a truly interdisciplinary collaboration between chemists, physicists, and biologists is required. To this end, we propose a european network collaboration between academic partners, who will take care of the development of new solutions for nanofabrication, and industrial partners implied in the field of the proposed application who will evaluate/develop the materials and act as advisors for risks arising during the project.

Convocatoria de propuestas

FP7-NMP-2008-SMALL-2
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Coordinador

CONSIGLIO NAZIONALE DELLE RICERCHE
Dirección
Piazzale Aldo Moro 7
00185 Roma
Italia
Tipo de actividad
Research Organisations
Aportación de la UE
€ 373 707,25
Contacto administrativo
Teresa Pellegrino (Dr.)

Participantes (10)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Francia
Aportación de la UE
€ 648 103
Dirección
Rue Michel Ange 3
75794 Paris
Tipo de actividad
Other
Contacto administrativo
Liliane Flabbée (Ms.)
UNIVERSITEIT TWENTE
Países Bajos
Aportación de la UE
€ 351 840
Dirección
Drienerlolaan 5
7522 NB Enschede
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Luisa De Cola (Prof.)
ASOCIACION CENTRO DE INVESTIGACIONCOOPERATIVA EN NANOCIENCIAS CIC NANOGUNE
España
Aportación de la UE
€ 239 416
Dirección
Tolosa Hiribidea 76
20018 San Sebastian
Tipo de actividad
Research Organisations
Contacto administrativo
Miguel Odriozola Braconier (Dr.)
DOMPE SPA
Italia
Aportación de la UE
€ 80 550
Dirección
Via Campo Di Pile
67100 L'aquila
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Maria Candida Cesta (Dr.)
UNIVERSIDAD DE SANTIAGO DE COMPOSTELA
España
Aportación de la UE
€ 225 772
Dirección
Colexio De San Xerome Praza Do Obradoiro S/n
15782 Santiago De Compostela
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Martin Cacheiro Martinez (Mr.)
UNIVERSIDAD COMPLUTENSE DE MADRID
España
Aportación de la UE
€ 151 417,75
Dirección
Avenida De Seneca 2
28040 Madrid
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Maribel Rodríguez Villa (Ms.)
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI
Italia
Aportación de la UE
€ 395 020
Dirección
Via Venezian 1
20133 Milan
Tipo de actividad
Research Organisations
Contacto administrativo
Dario Belluzzi (Dr.)
NANOVECTOR SRL
Italia
Aportación de la UE
€ 295 200
Dirección
Via Livorno 60
10144 Torino
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Paolo Gasco (Mr.)
MAGFORCE NANOTECHNOLOGIES AG
Alemania
Aportación de la UE
€ 347 210
Dirección
Max-dohrn-strasse 8 Gebaude B 5 2
10589 Berlin
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Petra Meier (Ms.)
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
Italia
Aportación de la UE
€ 327 720
Dirección
Via Morego 30
16163 Genova
Tipo de actividad
Research Organisations
Contacto administrativo
Gabriele Ballero (Mr.)