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MAGNETIC NANOCONTAINERS FOR COMBINED HYPERTHERMIA AND CONTROLLED DRUG RELEASE

Cel

The aim of this project is the assembly and the fabrication of a new generation of multifunctional nanostructures for performing combined hyperthermia and controlled drug release, specifically targeted to cancer cells. The “magnetic nanocontainers” we intend to develop can perform at the same time cell recognition, hyperthermia treatment, and, as a consequence of the heat and /or cell environment stimuli, the release of drug with high selectivity for ovarian carcinoma. These multifunctional tasks are made possible due to the inclusion of three main components: a) the magnetic nanoparticles, allowing detection by MRI, cancer treatment by hyperthermia and providing stimuli for drug release; b) the nanocontainers, which allow for drug encapsulation and protection from degradation, facilitate the release of the drug upon application of an external stimulus, such as heat, or an internal one, such as the acidic pH of the tumour cells; c) the antibody fragments attached to the surface of the magnetic nanocontainers to deliver them selectively to the ovarian cancer cells. The individual building blocks and their assemblies will be characterized with respect to physical, chemical, and biological features, followed by dissemination of the newly acquired knowledge. Cell culture experiments will allow to understand the performance of such nano-tools in vitro. Directed towards application in patients, in vivo animal studies will be carried out on the most successful magnetic nanocontainers. The objectives of this proposal cover a wide range of scientific fields, hence a truly interdisciplinary collaboration between chemists, physicists, and biologists is required. To this end, we propose a european network collaboration between academic partners, who will take care of the development of new solutions for nanofabrication, and industrial partners implied in the field of the proposed application who will evaluate/develop the materials and act as advisors for risks arising during the project.

Zaproszenie do składania wniosków

FP7-NMP-2008-SMALL-2
Zobacz inne projekty w ramach tego zaproszenia

Koordynator

CONSIGLIO NAZIONALE DELLE RICERCHE
Adres
Piazzale Aldo Moro 7
00185 Roma
Włochy
Rodzaj działalności
Research Organisations
Wkład UE
€ 373 707,25
Kontakt administracyjny
Teresa Pellegrino (Dr.)

Uczestnicy (10)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Francja
Wkład UE
€ 648 103
Adres
Rue Michel Ange 3
75794 Paris
Rodzaj działalności
Research Organisations
Kontakt administracyjny
Liliane Flabbée (Ms.)
UNIVERSITEIT TWENTE
Niderlandy
Wkład UE
€ 351 840
Adres
Drienerlolaan 5
7522 NB Enschede
Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Luisa De Cola (Prof.)
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN NANOCIENCIAS CIC NANOGUNE
Hiszpania
Wkład UE
€ 239 416
Adres
Tolosa Hiribidea 76
20018 San Sebastian
Rodzaj działalności
Research Organisations
Kontakt administracyjny
Miguel Odriozola Braconier (Dr.)
DOMPE SPA
Włochy
Wkład UE
€ 80 550
Adres
Via Campo Di Pile
67100 L'aquila
Rodzaj działalności
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt administracyjny
Maria Candida Cesta (Dr.)
UNIVERSIDAD DE SANTIAGO DE COMPOSTELA
Hiszpania
Wkład UE
€ 225 772
Adres
Colexio De San Xerome Praza Do Obradoiro S/n
15782 Santiago De Compostela
Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Martin Cacheiro Martinez (Mr.)
UNIVERSIDAD COMPLUTENSE DE MADRID
Hiszpania
Wkład UE
€ 151 417,75
Adres
Avenida De Seneca 2
28040 Madrid
Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Maribel Rodríguez Villa (Ms.)
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI
Włochy
Wkład UE
€ 395 020
Adres
Via Venezian 1
20133 Milan
Rodzaj działalności
Research Organisations
Kontakt administracyjny
Dario Belluzzi (Dr.)
NANOVECTOR SRL
Włochy
Wkład UE
€ 295 200
Adres
Via Livorno 60
10144 Torino
Rodzaj działalności
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt administracyjny
Paolo Gasco (Mr.)
MAGFORCE NANOTECHNOLOGIES AG
Niemcy
Wkład UE
€ 347 210
Adres
Max-dohrn-strasse 8 Gebaude B 5 2
10589 Berlin
Rodzaj działalności
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt administracyjny
Petra Meier (Ms.)
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
Włochy
Wkład UE
€ 327 720
Adres
Via Morego 30
16163 Genova
Rodzaj działalności
Research Organisations
Kontakt administracyjny
Gabriele Ballero (Mr.)