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Single or few molecules detection by combined enhanced spectroscopies

Objective

Future breakthroughs in the understanding of fundamental biological processes causing major diseases are expected from the development of miniaturized probes or microscopes able to detect and identify a single or a small number of molecules. The SingleMoleculeDetection (SMD) proposal will develop a unique device able to perform simultaneously and in a dynamic way force and spectroscopic measurements. We will design and fabricate novel devices for the generation of plasmon polaritons as well as combine photonic crystals and plasmonic nanolenses. These new devices will be able to detect few/single molecules through Raman, InfraRed and Terahertz (THz) signals and in combination with Atomic Force Microscopy and Optical Tweezer force spectroscopy with a spatial resolution in the sub-10 nm for Raman and IR and sub-100 nm for the THz region. The complete characterization of single unknown molecule will be demonstrated through: i- investigations on the chemical and physical properties of membrane receptors, such as rhodopsin, odorant receptors and ionic channels; ii- identification of new molecules involved in cancer development and metastasis. The new devices will allow the acquisition of THz images and we will explore the possibilities of this new spectral region for biomedical scanning. The SMD proposal is based on an original idea of the coordinator, prof. E. di Fabrizio and will be exploited thanks to the complementary expertise present in the different sites and to a tight coordination between the various groups. The design, fabrication and testing will be performed at UMG, TASC and CBM Integration in a single instrument will be carried out at TASC, CBM, IIT Nanotec, RUB. Validation activities will be performed by all the partners taking advantage of the world leading expertise of the TUDO and the STRATH- AC in spectroscopy of natural and artificial biological systems. The SME NANOTEC and CBM will provide the commercial exploitation of the obtained results.

Call for proposal

FP7-NMP-2008-SMALL-2
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Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

CONSORZIO PER IL CENTRO DI BIOMEDICINA MOLECOLARE SCARL
Address
Strada Statale 14 Km 163 5 Basovizza
34149 Trieste
Italy
Activity type
Research Organisations
EU contribution
€ 896 136,40
Administrative Contact
Anna Lucia Bellina (Ms.)

Participants (7)

UNIVERSITA DEGLI STUDI MAGNA GRAECIA DI CATANZARO
Italy
EU contribution
€ 271 466
Address
Viale Europa Localita Germaneto
88100 Catanzaro
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Roberto Sigilli (Mr.)
RUHR-UNIVERSITAET BOCHUM
Germany
EU contribution
€ 475 978
Address
Universitaetsstrasse 150
44801 Bochum
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Martina Havenith (Prof.)
TECHNISCHE UNIVERSITAT DORTMUND
Germany
EU contribution
€ 429 850
Address
August Schmidt Strasse 4
44227 Dortmund
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Daniel Schneider (Mr.)
UNIVERSITY OF STRATHCLYDE
United Kingdom
EU contribution
€ 499 232
Address
Richmond Street 16
G1 1XQ Glasgow
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Martin Gregory (Mr.)
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 267 448
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations
Administrative Contact
Martina Centazzo (Ms.)
Nanotec Electronica SL
Spain
EU contribution
€ 315 500
Address
Ronda De Poniente 12 2 C
28760 Tres Cantos Madrid
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Leonor Badorrey (Ms.)
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
Italy
EU contribution
€ 265 889,60
Address
Via Morego 30
16163 Genova
Activity type
Research Organisations
Administrative Contact
Gabriele Ballero (Mr.)