Objective
Fish are the only major dietary source for humans of omega-3 highly unsaturated fatty acids (HUFA) including eicosapentaenoic and docosahexaenoic acids that are crucial to the health of vertebrates and, with declining fisheries, farmed fish such as Atlantic salmon constitute an increasing proportion of the fish in the human diet. However, the current high use of fish oils (FO), derived from feed grade marine fisheries, in aquaculture feeds is unsustainable, and will constrain growth of aquaculture. The only sustainable alternative to FO are vegetable oils (VO), which can be rich in C18 polyunsaturated fatty acids such as linoleic and linolenic acids, but devoid of the n-3HUFA that are abundant in fish oils. Changes in fatty acid metabolism in salmon induced by VO replacement of FO in aquaculture diets can have a negative impact on the nutritional quality of the product for the human consumer by altering flesh fatty acid composition.
A greater understanding of the effects of VO replacement at a molecular level may lead to effective use of more sustainable aquaculture diets. Previous studies have shown that replacement of FO with VO leads to altered gene expression in salmon. The study aims to test three hypotheses; that changes in liver gene and protein express ion, and phenotype are associated; that gene expression in non-lethally obtained samples can be related to gene expression in liver; and that variation within any population can be related to variation in expression of specific genes.
The specific objectives are:
1. To determine effects of replacing dietary FO with VO on gene and protein expression in liver of salmon,
2. To determine associations between gene expression, protein expression and phenotype (as measured by flesh n-3HUFA content),
3. To compare gene expression pattern in non-lethally sampled tissues (fin clips and blood) with that of liver,
4. To determine levels of variation in gene and protein expression and phenotype within the population sampled.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- agricultural sciences agriculture, forestry, and fisheries fisheries
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences biological sciences biochemistry biomolecules lipids
- natural sciences biological sciences genetics RNA transcriptomes
- medical and health sciences health sciences nutrition
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
STIRLING
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.