Objective
The scientific aim of InduHeart is to produce novel comparative information on the generation, maintenance, characteristics of iPS cells in mouse and on their differentiation towards the cardiac lineage. InduHeart will also employ mouse embryonic stem (ES) cell lines to develop innovative methods for the targeted preparation of differentiated cardiac muscle cells. The characteristics of cardiomyocytes generated from iPS and Embryonic Stem (ES) cells will be compared and their ability to report disease phenotypes and drug responses faithfully will be investigated. Technical focus will be generating a novel and potentially patentable technology in Europe for reprogramming somatic cells to an embryonic state without the use of viral constructs, which have a perceived risk for future cell based therapy. This will lead towards the generation of iPS cells in a more predictable, controlled and safer way than previously. Overall, the results are expected to provide novel information on the pathways and differentiation events leading to a high percentage of cardiomyocytes in the special supplement based mouse ES cell differentiation system. These cardiomyocytes can serve also as useful tools for high-throughput screenings for pharmacological studies including efficacy, safety, and toxicology. InduHeart will contribute to the field of modern tissue engineering and regenerative medicine.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology tissue engineering
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences basic medicine toxicology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IRG-2008
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
2100 Goedoello
Hungary
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.