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Toward the development of peptide-based hydrogels for tissue regeneration applications with inherent antibacterial activity

Objectif

Hydrogels are heavily hydrated materials finding use as delivery vehicles in autologous tissue engineering. In one approach, healthy cells are first isolated from the patient and expanded in the lab. The cells are then encapsulated in a hydrogel and the resulting gel/cell construct is injected into the wound site where healing is catalyzed by the implanted cells. Although early efforts show promise, implant-centered infections can be problematic since the microenvironment of many hydrogels are not only ideal for the intended mammalian cells but also for opportunistic bacteria. In this proposal, a multidisciplinary approach entailing structure-based peptide design, biophysical and materials properties analysis as well as mammalian and bacterial cell culturing will be used to formulate a peptide-based hydrogel that meets the stringent requirements for mammalian cell encapsulation and delivery, yet is also inherently antibacterial. This work will result in novel materials that will find immediate use in tissue engineering.

Champ scientifique (EuroSciVoc)

Programme(s)

Thème(s)

Appel à propositions

FP7-PEOPLE-IOF-2008
Voir d’autres projets de cet appel

Régime de financement

MC-IOF - International Outgoing Fellowships (IOF)

Coordinateur

INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
Contribution de l’UE
€ 235 102,89
Adresse
AVENIDA PROF EGAS MONIZ
1649 028 Lisboa
Portugal
Région
Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa
Type d’activité
Research Organisations
Liens
Coût total
Aucune donnée