Objective
Recent findings, demonstrating a synergistic anticonvulsant interaction between two gamma-amino butyric acid transporter (GAT) antagonists, tiagabine and EF1502 prompt a need to elucidate the possible mechanisms underlying such an interaction.
The primary scientific aim of this project will be to study the interactions between GATs in controlled biological model systems: in human embrionic kidney (HEK293) cell lines and Xenopus laevisoocytes expressing different GAT subtypes and in cultured neurones and a strocytes from the central nervous system.
The methods to be used and learned through research include uptake studies in combination with radioactive detection and two-electrode voltage-clamp of substrate-induced currents. The Danish University of Pharmaceutical Sciences (DUPS) in Copenhagen, a former Marie Curie Training Site, is an internationally recognised educational- and research centre.
It's intersectorial (with close ties to the pharmaceutical industry) and interdisciplinary character provides an opportunity for the proposer to develop his scientific and personal career by getting international experience in a leading European research group. The home institution, the Chemical Research Centre of the Hungarian Academy of Sciences (CRC HAS) is a distinguished 'Centre of Excellence' in Budapest.
This is also an opportunity for both DUPS and the home institution, to realize a two-way transfer of knowledge through cooperation in research and training, in the field of neuropharmacology.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.