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Muscle Z-disk Protein Complexes: from atomic structure to physiological function

Objective

Movement is vital to all living organisms, from the transport of single molecules in cells to the movement of entire organisms. Sarcomeres are the smallest cellular unit behind the operation of skeletal and heart muscles. Furthermore, dysfunctional sarcomeres are responsible for a long list of diseases that reduce the quality of life and burden the health care sector throughout the world. Understanding the function of sarcomere Z-disk – the focus of MUZIC - requires knowledge ranging from cellular dynamics to structural details of individual molecules and complexes. Such knowledge of molecular and cellular mechanisms, in healthy and diseased muscle cells, should lead to novel treatments of muscle diseases. Generating such knowledge - at the interface between cellular and structural biology - requires research workers with a much broader training than is currently available. To provide this, a unique blend of cellular and structural biology laboratories with a focus on muscle research, united in the MUZIC network, will aim to: • Bridge the gap between cellular and structural biology by training young researchers as “Cellular Structural Biologists”. A training program will be created that meshes these disciplines and provides young researchers with a unique set of skills in methods, management and communication. Mentoring will play a crucial role in the training process • Critically advance knowledge of the molecular components and the cellular mechanisms involved in the function, dynamics and regulation of the muscle Z-disk. This will be achieved by studying the Z-disk at different levels of complexity, from atomic structure to physiological function, by combining molecular and cell biology approaches, together with investigation of the molecular structures Through training a new type of scientist with a unique set of skills, and through studies on muscles in both health and disease, this network shall have a profound impact on and future research in this area.

Field of science

  • /natural sciences/biological sciences/molecular biology/structural biology
  • /natural sciences/biological sciences/cell biology

Call for proposal

FP7-PEOPLE-ITN-2008
See other projects for this call

Funding Scheme

MC-ITN - Networks for Initial Training (ITN)

Coordinator

UNIVERSITAT WIEN
Address
Universitatsring 1
1010 Wien
Austria
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 459 369,85
Administrative Contact
Kristina Djinovic Carugo (Prof.)

Participants (8)

RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN
Germany
EU contribution
€ 216 010,30
Address
Regina Pacis Weg 3
53113 Bonn
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Daniela Hasenpusch (Ms.)
UNIVERSITA DEGLI STUDI DI PADOVA
Italy
EU contribution
€ 409 709,30
Address
Via 8 Febbraio 2
35122 Padova
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Daniela Pacchini (Ms.)
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 286 893,20
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations
Administrative Contact
Margret Fischer (Ms.)
JYVASKYLAN YLIOPISTO
Finland
EU contribution
€ 240 933
Address
Seminaarinkatu 15
40100 Jyvaskyla
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jari Ylanne (Prof.)
UNIVERSITY OF LEEDS
United Kingdom
EU contribution
€ 404 978,20
Address
Woodhouse Lane
LS2 9JT Leeds
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kathy Brownridge (Ms.)
KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 208 150,80
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Labbett (Mr.)
TECHNISCHE UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 197 860,30
Address
Arcisstrasse 21
80333 Muenchen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ulrike Ronchetti (Ms.)
Evitraproteoma AB
Sweden
EU contribution
€ 248 867,31
Address
Box 23052
10435 Stockholm
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Maria Dollhopf (Dr.)