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Timing and plasticity in the olivo-cerebellar system

Objective

Training young researchers to form the new generation of scientists is a must for our society. In this project we will use a multidisciplinary approach to investigate neuronal and circuit functions in the cerebellar network, which plays a critical role in sensori-motor control and is probably also involved in higher cognitive functions. The project will focus on timing and plasticity in the network. Recent results, largely achieved in our own groups, have shown indeed that timing and plasticity play a critical role in determining the computational properties of the circuit. Different groups will be involved in investigating these processes in the granular layer, the molecular layer, the deep cerebellar nuclei and the inferior olive and particular emphasis will be given to attempts at reconstructing hypotheses on the link between these circuit components. We will therefore employ and develop new technologies including various applications of patch-clamping, imaging and mathematical modeling, as well as molecular biology and behavioral analysis in mutant mice. The project is based on a previous extensive scientific interchange between the participating groups, which have already developed collaborative activities in the past. We envisage to employ young scientists in PhD and postdoctoral programs (16 ESR and 3 ER) and to promote their interchange among our laboratories, both by developing collaborative investigations and by organizing workshops and training courses on scientific issues, techniques, and general skills. The participation of industries will ensure research and training on productive aspects and on management of science, strongly improving the effectiveness of the network in preparing new scientific operators and leaders in the emerging field of Cellular/System Neuroscience and Neurocomputation fostering application in the bio-medical, bio-engineering and IST sectors.

Call for proposal

FP7-PEOPLE-ITN-2008
See other projects for this call

Coordinator

CONSORZIO NAZIONALE INTERUNIVERSITARIO PER LE SCIENZE FISICHE DELLA MATERIA
Address
Via Ostiense 159
00154 Roma
Italy
Activity type
Research Organisations
EU contribution
€ 643 829
Administrative Contact
Piergianni Daniele (Dr.)

Participants (6)

UNIVERSITEIT ANTWERPEN
Belgium
EU contribution
€ 414 216
Address
Prinsstraat 13
2000 Antwerpen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anne Adams (Ms.)
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 441 551
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christiaan Innocentius De Zeeuw (Dr.)
UCL Elizabeth Garrett Anderson Institute for Women’s Health
United Kingdom
EU contribution
€ 882 292
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Greta Borg-Carbott (Ms.)
ECOLE NORMALE SUPERIEURE
France
EU contribution
€ 428 859
Address
45, Rue D'ulm
75230 Paris Cedex 05
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anne Cormier (Ms.)
THE HEBREW UNIVERSITY OF JERUSALEM
Israel
EU contribution
€ 419 171
Address
Edmond J Safra Campus Givat Ram
91904 Jerusalem
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jane Turner (Ms.)
SYNAPTOLOGICS BV
Netherlands
EU contribution
€ 429 893
Address
Achillesstraat 28 2
1008 BA Amsterdam
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Annemieke A Steenbergen (Ms.)