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Bio-inspired Design of Catalysts for Selective Oxidations of C-H and C=C Bonds

Objective

The selective functionalization of C-H and C=C bonds remains a formidable unsolved problem, owing to their inert nature. Novel alkane and alkene oxidation reactions exhibiting good and/or unprecedented selectivities will have a big impact on bulk and fine chemistry by opening novel methodologies that will allow removal of protection-deprotection sequences, thus streamlining synthetic strategies. These goals are targeted in this project via design of iron and manganese catalysts inspired by structural elements of the active site of non-heme enzymes of the Rieske Dioxygenase family. Selectivity is pursued via rational design of catalysts that will exploit substrate recognition-exclusion phenomena, and control over proton and electron affinity of the active species. Moreover, these catalysts will employ H2O2 as oxidant, and will operate under mild conditions (pressure and temperature). The fundamental mechanistic aspects of the catalytic reactions, and the species implicated in C-H and C=C oxidation events will also be studied with the aim of building on the necessary knowledge to design future generations of catalysts, and provide models to understand the chemistry taking place in non-heme iron and manganese-dependent oxygenases.

Field of science

  • /natural sciences/chemical sciences/inorganic chemistry/inorganic compounds
  • /natural sciences/chemical sciences/electrochemistry/electrolysis
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/enzymes

Call for proposal

ERC-2009-StG
See other projects for this call

Funding Scheme

ERC-SG - ERC Starting Grant

Host institution

UNIVERSITAT DE GIRONA
Address
Placa Sant Domenec 3
17004 Girona
Spain
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 299 998
Principal investigator
Miguel Costas Salgueiro (Dr.)
Administrative Contact
Helena Montiel (Dr.)

Beneficiaries (1)

UNIVERSITAT DE GIRONA
Spain
EU contribution
€ 1 299 998
Address
Placa Sant Domenec 3
17004 Girona
Activity type
Higher or Secondary Education Establishments
Principal investigator
Miguel Costas Salgueiro (Dr.)
Administrative Contact
Helena Montiel (Dr.)