Objective
During learning, reversible physiological changes in synaptic transmission take place in the central nerve system (CNS). These changes must then be stabilized or consolidated in order for memory to persist. Much evidence indicates that memories are created by alterations in glutamate-dependent excitatory synaptic transmission. The creation of stable, persistent changes (long-term memory - LTM) requires gene expression and protein synthesis. However, molecular changes are transient and so, on their own, are insufficient to explain LTM. It is well accepted that structural changes in synaptic morphology, occurring either consequent to protein synthesis or parallel with it are also necessary. The three dimensional structural organization of dendritic spines was n ever investigated at the molecular level.
The research proposed here aims to investigate the 3D organization of dendritic spines using cryo electron tomography at different stages of neuronal growth and in response do various neuronal stimuli. Within the tomograms, methods will be devoted for labelling and identification of macromolecular complexes. The combination of cryo electron tomography and the development of novel methods for intracellular macromolecular complex identification will give us deeper insight into structural mechanisms associated with LTM. Cryo electron tomography is the tool of choice for structural investigation at the molecular level of intact cells preserved in their native environment in a frozen-hydrated state.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences physical sciences optics microscopy electron microscopy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
MUENCHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.