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Fatty liver: Inhibition of Progression

Objectif

Non-alcoholic fatty liver disease (NAFLD) has become one of the top concerns for the practising hepatogastroenterologist due to the obesity epidemic and its potential to progress to advanced liver disease which significantly impacts on overall and liver-related mortality. The aim of the FLIP (Fatty Liver: Inhibition of Progression) project is to understand and prevent the progression of liver disease in NAFLD. FLIP is a consortium of basic scientists and practising clinical hepatologists with an established track record and focus on research into the underlying mechanisms and management of patients with NAFLD. Therefore FLIP provides a unique opportunity to assemble the largest European cohort of patients with histologically diagnosed NAFLD with clinical and epidemiological data and with biobanks of DNA, frozen liver tissue and serum. These will be used in a wide range of collaborative inter-disciplinary research projects aimed at addressing key unanswered questions related to the mechanisms and consequences of liver injury in NAFLD and the development of novel preventive and therapeutic strategies. The main outcomes of FLIP will be new insights in the progression of liver disease in NAFLD in terms of initiating mechanisms and patients at risk, innovative diagnostic methods particularly adapted for large-scale screening and prognostic evaluation, improved implementation of lifestyle changes, collaboration with leading biotechnological or pharmaceutical companies in order to translate to the market diagnostic tests or newly identified molecular targets for pharmacological therapy. By disseminating the project’s results, FLIP will further help the European Community to suggest guidelines on the management of this emerging liver disease. The long-term goal is to lay the foundations for the future of NAFLD research in Europe by creating a Collaborative Research Network on NAFLD that will continue the work initiated by the FLIP consortium.

Appel à propositions

FP7-HEALTH-2009-single-stage
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Coordinateur

ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
Adresse
3 Avenue Victoria
75000 Paris
France
Type d’activité
Research Organisations
Contribution de l’UE
€ 957 876,15
Contact administratif
Christophe Misse (Mr.)

Participants (16)

Biopredictive
France
Contribution de l’UE
€ 361 400
Adresse
Rue Du Bac 40
75007 Paris
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Jean-Marie Castille (Mr.)
AYMING
France
Contribution de l’UE
€ 229 720
Adresse
Rue Chaptal 114
92300 Levallois-perret
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Franck Noumbissie (Mr.)
UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom
Contribution de l’UE
€ 1 303 548
Adresse
Kings Gate
NE1 7RU Newcastle Upon Tyne
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Aleona Blinova (Ms.)
UNIVERSITY OF BRISTOL
United Kingdom
Contribution de l’UE
€ 185 776
Adresse
Beacon House Queens Road
BS8 1QU Bristol
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Vince Boyle (Mr.)
ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Italie
Contribution de l’UE
€ 268 100
Adresse
Via Zamboni 33
40126 Bologna
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Diego Torresan (Dr.)
UNIVERSITA DEGLI STUDI DI FIRENZE
Italie
Contribution de l’UE
€ 237 040
Adresse
Piazza San Marco 4
50121 Florence
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Fabio Marra (Prof.)
UNIVERSITA DEGLI STUDI DI TORINO
Italie
Contribution de l’UE
€ 533 597
Adresse
Via Giuseppe Verdi 8
10124 Torino
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Elisabetta Bugianesi (Dr.)
UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA
Italie
Contribution de l’UE
€ 185 594
Adresse
Via Universita 4
41121 Modena
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Paola Borella (Prof.)
MEDIZINISCHE UNIVERSITAT GRAZ

Participation terminée

Autriche
Adresse
Auenbruggerplatz 2
8036 Graz
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Michael Trauner (Prof.)
UNIVERSITAET BERN
Suisse
Contribution de l’UE
€ 348 234
Adresse
Hochschulstrasse 6
3012 Bern
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Jean-François Dufour (Prof.)
SERVICIO ANDALUZ DE SALUD
Espagne
Contribution de l’UE
€ 230 200
Adresse
Avenida De La Constitucion 18
41071 Sevilla
Type d’activité
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Contact administratif
Manuel Romero-Gómez (Dr.)
REGION HOVEDSTADEN
Danemark
Contribution de l’UE
€ 349 873
Adresse
Kongens Vaenge 2
3400 Hillerod
Type d’activité
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Contact administratif
Kate Livemore (Ms.)
ASTELLAS PHARMA EUROPE BV

Participation terminée

Pays-Bas
Contribution de l’UE
€ 35 602,85
Adresse
Sylviusweg 84
2333 BE Leiden
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Steve Van Os (Dr.)
FONDAZIONE ITALIANA FEGATO ONLUS
Italie
Contribution de l’UE
€ 209 520
Adresse
Area Science Park, Bldg Q, Ss14, Km 163.5
34012 Trieste
Type d’activité
Research Organisations
Contact administratif
Sabrina Corsucci (Ms.)
UNIVERSITA POLITECNICA DELLE MARCHE
Italie
Contribution de l’UE
€ 207 240
Adresse
Piazza Roma 22
60121 Ancona
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Gianluca Svegliati Baroni (Dr.)
MEDIZINISCHE UNIVERSITAET WIEN
Autriche
Contribution de l’UE
€ 340 156,80
Adresse
Spitalgasse 23
1090 Wien
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Josef Smolen