Objective Inherited dilated cardiomyopathies (DCM) are monogenic disorders caused by mutations in more than 30 genes, characterised by substantial phenotype heterogeneity. DCM affects 1:2.500 individuals and is the major cause of heart transplantation and death for non-ischaemic heart failure in adolescents and young adults. Currently, less than 1% of patients with familial DCM are genotyped in Europe. The INHERITANCE (INtegrated HEart Research In TrANslational genetics of dilated Cardiomyopathies in Europe) consortium propose to investigate over 2,000 existing DCM patients and their relatives in order to translate novel insights on the aetiology and pathophysiology of inherited cardiomyopathies into innovative disease specific diagnostic and treatment strategies. The consortium members share common clinical, scientific and ethical standards with respect to patient care and family screening, and have individual expertise in the clinical management and molecular genetics of inherited cardiomyopathies. The INHERITANCE strategy is to integrate genomic, proteomic, structural and functional studies exploring the molecular cascades arising from causative mutations with innovative clinical assessments in order to understand disease expression, evolution and to explore novel therapeutic strategies both in humans and in animal models. The immediate benefits will include preclinical and presymptomatic diagnosis, family-tailored clinical work-up, optimisation of existing treatment strategies and cost-effective use of medical resources. In the medium term, these studies will catalyse the development of new disease specific protocols, and will provide a model for the exploration of ground-breaking genetic and pharmacological therapies. Fields of science natural sciencesbiological sciencesmolecular biologymolecular geneticsmedical and health sciencesbasic medicinephysiologypathophysiologynatural sciencesbiological sciencesgeneticsmutationmedical and health sciencesclinical medicinecardiologymedical and health sciencesclinical medicinetransplantation Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2009-2.4.2-3 - Translation of basic knowledge on inherited cardiomyopathies into clinical practice Call for proposal FP7-HEALTH-2009-single-stage See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator FONDAZIONE IRCCS POLICLINICO SAN MATTEO Address Viale golgi 19 27100 Pavia Italy See on map Region Nord-Ovest Lombardia Pavia Activity type Research Organisations Administrative Contact Franco Marazza (Dr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 573 127,00 Participants (10) Sort alphabetically Sort by EU Contribution Expand all Collapse all UCL Elizabeth Garrett Anderson Institute for Women’s Health United Kingdom EU contribution € 200 672,00 Address Gower street WC1E 6BT London See on map Region London Inner London — West Camden and City of London Activity type Higher or Secondary Education Establishments Administrative Contact Greta Borg-Carbott (Ms.) Links Contact the organisation Opens in new window Website Opens in new window REGION VASTERBOTTEN Sweden EU contribution € 71 700,00 Address Koksvagen 11 901 89 Umea See on map Region Norra Sverige Övre Norrland Västerbottens län Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Simon Lindgren (Mr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITATSKLINIKUM HEIDELBERG Germany EU contribution € 445 808,00 Address Im neuenheimer feld 672 69120 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Higher or Secondary Education Establishments Administrative Contact Thorsten Brietz Links Contact the organisation Opens in new window Website Opens in new window INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution € 330 040,00 Address Rue de tolbiac 101 75654 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Isabelle Verdier (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Health in Code SL Spain EU contribution € 246 660,00 Address Ed. fortin. hospial marítimo de oza. as xubias 15006 A coruna See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Lorenzo Monserrat (Dr.) Links Contact the organisation Opens in new window Website Opens in new window THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE United Kingdom EU contribution € 236 755,00 Address Trinity lane the old schools CB2 1TN Cambridge See on map Region East of England East Anglia Cambridgeshire CC Activity type Higher or Secondary Education Establishments Administrative Contact Damien Briggs (Mr.) Links Contact the organisation Opens in new window Website Opens in new window AARHUS UNIVERSITETSHOSPITAL, SKEJBY Denmark EU contribution € 168 416,00 Address Brendstrupgaardsvej 100 8200 Aarhus n See on map Activity type Research Organisations Administrative Contact Jens Mogensen (Dr.) Links Contact the organisation Opens in new window Website Opens in new window ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM Netherlands EU contribution € 209 310,00 Address Meibergdreef 15 1105AZ Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Higher or Secondary Education Establishments Administrative Contact Lieve Peeters (Ms.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITA DEGLI STUDI DI PAVIA Italy EU contribution € 184 095,00 Address Strada nuova 65 27100 Pavia See on map Region Nord-Ovest Lombardia Pavia Activity type Higher or Secondary Education Establishments Administrative Contact Riccardo Bellazzi (Prof.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITA DEGLI STUDI DI MILANO Italy EU contribution € 204 208,00 Address Via festa del perdono 7 20122 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Higher or Secondary Education Establishments Administrative Contact Stefania Varotto (Dr.) Links Contact the organisation Opens in new window Website Opens in new window
