Objective
The glycosylation of proteins is regarded as one of the most complex modification within eukaryotes.
This modification serves to define the biological role of the glycosylated protein in processes such stability and solubility of proteins, immune response, intracellular targeting, intercellular recognition and protein folding. An evident complication of the study of naturally occuring glycoproteins and their role in the before mentioned biological processes is their occurrence as glycoforms. As each component of this microheterogeneous population exhibits different properties, structure-activity relationship studies are not possible.
Besides this, the therapeutic application of non-homogeneous glycoproteins may in the near future be regarded as undesired by the regulatory authorities. With the desire to solve this problem, this proposal presents the development of a novel approach, named Native Chemical Glycosylation, toward the synthesis of well-defined homogeneous glycoproteins.
Fields of science (EuroSciVoc)
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
OXFORD
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.