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CARDIO REPAIR EUROPEAN MULTIDISCIPLINARY INITIATIVE

Objective

Ischemic Heart Disease (IHD) is the biggest single cause of death in Europe and in the developed world. Angioplasty and stents are successful in re-establishing perfusion of ischemic myocardium and have helped to reduce early mortality after acute myocardial infarction (AMI). However damaged tissue is not recovered and, therefore, this is always followed by cardiac remodelling and Chronic Heart Failure (CHF). CHF is a terminal disease with an annual mortality rate of ~18% with no cure besides heart transplantation, only available to a minority of patients. Autologous cell therapy has been proposed as a solution and clinically tested but has proven marginally effective at best. Its cost and the complexity of clinical procedures make it unsuitable for treating the large number of patients that need affordable and readily available products to treat the acute phase of the disease. Moreover, most of these approaches are predicated on the outmoded concept that the adult human myocardium lacks regenerative capacity. Recent findings show that adult myocardium harbours a population of resident pluripotent cells with the characteristics of true cardiac stem cells (CSC) able to regenerate contractile myocardium. This opens novel therapeutic avenues capable of producing real anatomical and functional regeneration. The CARE-MI proposal addresses the clinical implementation of this recent paradigmatic change. We will clinically test and further develop myocardial regenerative therapies based on the in situ activation, multiplication and differentiation of the endogenous CSCs with the aim to provide therapies that are: a)Affordable, in terms of the production costs of the medicinal product b)Readily and widely available, implying that the product may be easily stored and readied for application at all times at minimum cost. c)Easy to apply and compatible with current clinical standard of care for AMI, including the widespread use of PTCA interventions

Field of science

  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /social sciences/sociology/demography/mortality
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/pharmaceutical drug

Call for proposal

FP7-HEALTH-2009-single-stage
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.)
Address
Calle Melchor Fernandez Almagro 3
28029 Madrid
Spain
Activity type
Research Organisations
EU contribution
€ 1 526 627,11
Administrative Contact
Luz Alvarez Vilela (Ms.)

Participants (19)

Consorcio para la gestión del Centro de Cirugía de Mínima Invasión

Participation ended

Spain
EU contribution
€ 1 086 559
Address
Ctra. N-521 Km.41.8
10071 Cáceres
Activity type
Research Organisations
Administrative Contact
Miguel álvarez Bayo (Mr.)
CORETHERAPIX S.L
Spain
EU contribution
€ 1 753 119
Address
Plaza De La Encina 10 Nucleo 1 Planta 3
28760 Madrid
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Juan Sebastián Ruiz (Mr.)
INNOCORE TECHNOLOGIES BV
Netherlands
EU contribution
€ 1 088 443,64
Address
L.j. Zielstraweg 1
9713 GX Groningen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Rob Steendam (Dr.)
NANOMI BV
Netherlands
EU contribution
€ 1 088 443,64
Address
Zutphenstraat 51
7575 EJ Oldenzaal
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Gert Veldhuis (Dr.)
PROTEIN PRODUCTION SERVICES LTD

Participation ended

Israel
EU contribution
€ 343 696,95
Address
Golda Meir St - Kiryat Weizmann Science Park 7
74036 Ness Ziona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Elisheva Yonish-Rouach (Dr.)
FUNDACION CENTRO DE CIRUGIA DE MINIMA INVASION JESUS USON
Spain
Address
Carretera Nacional 521 Km 41 8
10071 Caceres
Activity type
Research Organisations
Administrative Contact
Miguel álvarez Bayo (Mr.)
INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLOGICA
Portugal
EU contribution
€ 377 440
Address
Avenida Da Republica Quinta Do Marques
2781-901 Oeiras
Activity type
Research Organisations
Administrative Contact
Nuno Santos (Dr.)
INSTITUT CATALA DE LA SALUT
Spain
EU contribution
€ 407 746
Address
Gran Via De Les Corts Catalanes 587
08007 Barcelona
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Lluis Masso (Mr.)
LIVERPOOL JOHN MOORES UNIVERSITY

Participation ended

United Kingdom
EU contribution
€ 637 956,64
Address
Rodney Street 2 Egerton Court
L3 5UX Liverpool
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Georgina Ellison (Dr.)
UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS
Germany
EU contribution
€ 313 200
Address
Robert-koch-strasse 40
37075 Goettingen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christiane Hennecke (Ms.)
PHILIPS MEDICAL SYSTEMS NEDERLAND BV
Netherlands
EU contribution
€ 40 159
Address
Veenpluis 6
5684 PC Best
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Patrick Keur (Mr.)
PHILIPS IBERICA SA
Spain
EU contribution
€ 111 355
Address
Calle Maria De Portugal 1
28050 Madrid
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ignacio Ayerdi Salazar
HLA ET MEDECINE
France
EU contribution
€ 468 080
Address
Avenue Claude Vellefaux 1
75010 Paris
Activity type
Research Organisations
Administrative Contact
Muriel Brandel (Ms.)
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 982 731
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Elke Lammertyn (Dr.)
UNIVERZA V LJUBLJANI
Slovenia
EU contribution
€ 200 446,80
Address
Kongresni Trg 12
1000 Ljubljana
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Blaz Zupan (Dr.)
VIB VZW

Participation ended

Belgium
EU contribution
€ 28 484,66
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Activity type
Research Organisations
Administrative Contact
Rik Audenaert (Mr.)
FARMA-CROS IBERICA S.L.
Spain
EU contribution
€ 173 700
Address
Castilla La Mancha. Poligono Industrial Camporrosso 7
02520 Albacete
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Juan López-Belmonte (Dr.)
VIVOTECNIA RESEARCH SL
Spain
EU contribution
€ 179 861
Address
Calle Santiago Grisolia 2
28760 Tres Cantos - Madrid
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jesús Rodríguez
KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 497 053,36
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Labbet (Mr.)