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Luminescent polymers for in vivo imaging of amyloid signatures

Objective

In this project we seek to develop new smart imaging molecular tools for combating neurodegenerative diseases such as Alzheimer’s disease and prion diseases. Emphasis is put on translational applied research for the development and validation of novel properly functionalized luminescent conjugated polymers (LCP) that via modern imaging technology can give rise to entirely new and innovative methodology for studying neurodegenerative diseases. The objectives include the development of novel imaging agents that can be utilized for biomedical research, diagnosis, monitoring and prognosis, and for support and guidance of therapeutic interventions for Alzheimer’s disease and prion diseases. The consortium is composed of expert groups in experimental optics, polymer synthesis, magnetic resonance imaging (MRI), synthesis of functionalized magnetic nanoparticles, amyloid structure, AD mouse models, clinical AD, and prion diseases. At the same time this project establishes strategic links between mainly SME based Industries, expert researchers at universities and principal users in terms of hospitals. The project consortium will develop and share an efficient plan for dissemination and exploitation of the project results.

Field of science

  • /natural sciences/chemical sciences/polymer science
  • /medical and health sciences/basic medicine/neurology/alzheimer
  • /engineering and technology/medical engineering/diagnostic imaging/magnetic resonance imaging

Call for proposal

FP7-HEALTH-2009-single-stage
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

LINKOPINGS UNIVERSITET
Address
Campus Valla
581 83 Linkoping
Sweden
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 294 852,80
Administrative Contact
Magnus Fredriksson (Dr.)

Participants (7)

UNIVERSITE LYON 1 CLAUDE BERNARD
France
EU contribution
€ 532 400
Address
Boulevard Du 11 Novembre 1918 Num43
69622 Villeurbanne Cedex
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Javier Olaiz (Dr.)
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
EU contribution
€ 663 372
Address
Geschwister-scholl-platz
72074 Tuebingen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mathias Jucker (Prof.)
NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU
Norway
EU contribution
€ 654 249
Address
Hogskoleringen 1
7491 Trondheim
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mikael Lindgren (Prof.)
University of Zurich
Switzerland
EU contribution
€ 558 867
Address
Ramistrasse 71
8006 Zurich
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Adriano Aguzzi (Prof.)
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
EU contribution
€ 506 144
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eveline Fräßdorf (Ms.)
GENOVIS AB
Sweden
EU contribution
€ 255 761,60
Address
Scheelvaegen 22
22007 Lund
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Sarah Fredriksson (Dr.)
APPLIED SPECTRAL IMAGING LTD
Israel
EU contribution
€ 512 448,40
Address
Hamatechet 4
10551 Migdal Haemek
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Alaluf Orit (Dr.)