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The targeted development of a new generation Vaccine for Schistosomiasis

Objective

The aim of this project is to develop a new generation vaccine for schistosomiasis. The vaccine will be based on exposed proteins and/or glycans of the vulnerable skin stage schistosomula, making it safe and effective. The life stage-specific vaccine target selection strategy is based on state-of-the-art schistosomal transcriptomics and glycomics technologies and data, and unique serum and sample libraries from endemic areas will be the key to identifying protective immune responses and effective targets. Preclinical in vitro (cellular and whole parasite) and in vivo (rat model) testing of protective antigens with respect to cellular responses and effective parasite killing are part of the development pipeline. Analysis of human T- and B-cell responsiveness is an integral part of the approach. A unique SME-led approach to potentiate the effect of immunisation by use of engineering engineered antibodies will also be part of the project. The project involves strong participation of researchers from four schistosomiasis-endemic countries, and several European groups all with a long history of successful collaboration.

Call for proposal

FP7-HEALTH-2009-single-stage
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Coordinator

ACADEMISCH ZIEKENHUIS LEIDEN
Address
Albinusdreef 2
2333 ZA Leiden
Netherlands

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Linda Ouwerkerk (Ms.)
EU contribution
€ 1 179 680

Participants (12)

INSTITUT PASTEUR DE LILLE FONDATION
France
EU contribution
€ 363 030
Address
Rue Du Professeur Calmette 1
59019 Lille

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Activity type
Research Organisations
Administrative Contact
Fabienne Jean (Dr.)
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 547 160
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
David William Dunne (Prof.)
KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 180 800
Address
Norregade 10
1165 Kobenhavn

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ivan Kristoffersen (Mr.)
FORSCHUNGSZENTRUM BORSTEL
Germany
EU contribution
€ 273 525
Address
Parkallee 1-40
23845 Borstel

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Activity type
Research Organisations
Administrative Contact
Katharina Lötzer (Dr.)
ABERYSTWYTH UNIVERSITY
United Kingdom
EU contribution
€ 322 400
Address
Visualisation Centre Penglais
SY23 3BF Aberystwyth

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Emyr Reynolds (Mr.)
TRION Research GmbH
Germany
EU contribution
€ 181 550
Address
Am Klopferspitz 19
82152 Martinsried

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Petra Simml (Ms.)
Fondation international de l'Hopital de Dr. Albert Schweitzer de LAMBARENE
Gabon
EU contribution
€ 93 411,54
Address
Hopital Albert Schweitzer Na
13901 Lambarene

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Activity type
Other
Administrative Contact
Saadou Issifou (Dr.)
UNIVERSITY OF GHANA
Ghana
EU contribution
€ 184 860
Address
Legon Boundary Road
N/A Legon Accra

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Daniel Boakye (Prof.)
MINISTRY OF HEALTH
Uganda
EU contribution
€ 180 000
Address
Bombo Road 15
1661 Kampala

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Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Narcis B Kabatereine (Dr.)
KENYA MEDICAL RESEARCH INSTITUTE
Kenya
EU contribution
€ 186 570
Address
Off Mbagathi Way
00200 Nairobi

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Activity type
Research Organisations
Administrative Contact
Solomon Mpoke (Dr.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
Address
Rue Michel Ange 3
75794 Paris

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Activity type
Research Organisations
Administrative Contact
Gilles Pulvermulller (Mr.)
Centre de Recherches Medicales de Lambaréné
Gabon
EU contribution
€ 106 988,46
Address
Na
118 Lambaréné

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Activity type
Research Organisations
Administrative Contact
Olouyomi Scherif Adegnika