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BiO-dOSimetric Tools for triagE to Responders

Objective

The effective management of an incident involving exposure of large numbers of people to radioactive material, whether accidental or following malevolent use of radioactivity, requires a mechanism for rapid triage of exposed persons. The BOOSTER project addresses this requirement under Security Topic SEC-2009-4.3.2 – Bio-dosimetric tools to manage radiological casualties. Current biodosimetric approaches frequently involve cytogenetics. The analysis of dicentric/ ring chromosomes is the mechanism of choice for precise estimation of an individual’s exposure. Current optimisation of such analyses involves the automation of various steps in the process. However, chromosome analyses are performed on the first mitosis post-exposure and thus a significant limiting factor remains a cell culture step (2 days) that is impossible to reduce. New biodosimeters are required that may not bring the same precision as cytogenetic analysis but will permit triage in the first hours post-accident into three populations (i.e. to identify individuals that require no further intervention, those who require close follow-up and those who require hospitalisation). BOOSTER is a capability project designed to research and develop new bio-dosimetric tools in order to quickly evaluate the level of potential casualties, determine by appropriate sensors their consequences, allow an efficient triage of exposed people, integrate a useful and usable toolbox, train civil protection operators and define commercial exploitation potentialities. The BOOSTER project will use an integrated approach to deliver new bio-dosimetric tools. We propose to optimise existing tools for assessment of a radiological situation and to develop novel biodosimetric procedures for estimation of radiation exposure in cells from patients. These approaches will be combined in a prognostic toolkit that will allow effective management of exposed persons presenting at triage.

Field of science

  • /natural sciences/biological sciences/genetics and heredity/chromosome
  • /social sciences/sociology/industrial relations/automation

Call for proposal

FP7-SEC-2009-1
See other projects for this call

Funding Scheme

CP - Collaborative project (generic)

Coordinator

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
Address
Rue Leblanc 25
75015 Paris 15
France
Activity type
Research Organisations
EU contribution
€ 973 137
Administrative Contact
Brigitte Nicolas (Ms.)

Participants (6)

NATIONAL UNIVERSITY OF IRELAND GALWAY
Ireland
EU contribution
€ 699 876
Address
University Road
H91 Galway
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Roger Sweetman (Mr.)
KARLSRUHER INSTITUT FUER TECHNOLOGIE
Germany
EU contribution
€ 501 750
Address
Kaiserstrasse 12
76131 Karlsruhe
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Natascha Wallburg (Ms.)
IZOTOPKUTATO INTEZET - MAGYAR TUDOMANYOS AKADEMIA
Hungary
EU contribution
€ 281 500
Address
Konkoly Thege M. 29-33
1121 Budapest
Activity type
Research Organisations
Administrative Contact
Ildikó Grób
CANBERRA FRANCE
France
EU contribution
€ 334 637
Address
Rue Des Hérons 1
78180 Montigny Les Bretonneux
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Hervé Toubon (Mr.)
UNIVERSITAT POLITECNICA DE VALENCIA
Spain
EU contribution
€ 384 191
Address
Camino De Vera Sn Edificio 3A
46022 Valencia
Activity type
Higher or Secondary Education Establishments
Administrative Contact
José Antonio Pérez Garcia (Mr.)
ORSZAGOS ATOMENERGIA HIVATAL
Hungary
EU contribution
€ 109 200
Address
Fenyes Adolf 4
1036 Budapest
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Kristof Horvath (Dr.)