Objective Xenon biosensors have an outstanding potential to increase the significance of magnetic resonance imaging (MRI) in molecular imaging and to combine the advantages of MRI with the high sensitivity of hyperpolarized Xe-129 and the specificity of a functionalized contrast agent. Based on new detection schemes (Hyper-CEST method) in Xe MRI, this novel concept in molecular diagnostics will be made available for biomedical applications. The advancement focuses on high-sensitivity in vitro diagnostics for localization of tumour cells in cell cultures and first demonstrations on animal models based on a transferrin-functionalized biosensor. Such a sensor will enable detection of subcutaneous tumours at high sensitivity without any background signal. More detailed work on the different available Hyper-CEST contrast parameters focuses on an absolute quantification of new molecular markers that will improve non-invasive tumour diagnostics significantly. NMR detection of functionalized Xe biosensors have the potential to close the sensitivity gap between modalities of nuclear medicine like PET/SPECT and MRI without using ionizing radiation or making compromises in penetration depth like in optical methods. Fields of science engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsbiosensorsnatural scienceschemical sciencesinorganic chemistrynoble gasesmedical and health sciencesclinical medicineradiologynuclear medicinenatural sciencesphysical sciencesnuclear physicsengineering and technologymedical engineeringdiagnostic imagingmagnetic resonance imaging Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) ERC-SG-LS7 - Applied life sciences, biotechnology and bioengineering: agricultural, animal, fishery, forestry/food sciences; biotechnology, chemical biology, genetic engineering, synthetic biology, industrial biosciences; environmental biotechnology. Call for proposal ERC-2009-StG See other projects for this call Funding Scheme ERC-SG - ERC Starting Grant Coordinator FORSCHUNGSVERBUND BERLIN EV Address Rudower chaussee 17 12489 Berlin Germany See on map Region Berlin Berlin Berlin Activity type Research Organisations Administrative Contact Anne Höner (Dr.) Principal investigator Leif Schröder (Dr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 1 848 600,00 Beneficiaries (1) Sort alphabetically Sort by EU Contribution Expand all Collapse all FORSCHUNGSVERBUND BERLIN EV Germany EU contribution € 1 848 600,00 Address Rudower chaussee 17 12489 Berlin See on map Region Berlin Berlin Berlin Activity type Research Organisations Administrative Contact Anne Höner (Dr.) Principal investigator Leif Schröder (Dr.) Links Contact the organisation Opens in new window Website Opens in new window
