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Biomolecular Motor Systems: From Cellular Function to Nanotechnological Applications

Objective

This interdisciplinary project aims (i) to understand intracellular transport processes on a molecular level using novel nano-optical imaging tools and (ii) to use the insight from cellular systems to operate biomolecular motor systems in engineered environments for the fulfillment of complex nanotechnological tasks. Building on experience in optical microscopy and single molecule biophysics the research group will develop and apply nanotechnology-based tools to study the dynamical functioning of microtubule-based motor proteins in vitro and in vivo with nanometer resolution in three dimensions. These studies are expected to broaden the general knowledge about the design principles of molecular machines as well as the principles by which they interact with each other. This knowledge will - in return - pave the road for applications of these highly evolved transport machineries for a wide range of self-organizing nanofunctions in engineered environments. In contrast to conventional "macroscopic" top-down or "atomic" bottom-up approaches, a driving factor for this research is the capability of cellular machines to work in parallel, thus enabling the efficient fabrication and detection of nanostructures. The project will be strongly focussing on the interface between molecular cell biology and nanotechnology. With respect to the applied ERC funding, the project goals can be described by: Goal 1: Single-molecule studies on motor proteins using optical 3D-nanometer imaging, Goal 2: Investigation of cooperative effects in multi-motor transport, Goal 3: External control over transport systems in engineered environments, and Goal 4: Application of motor systems for nano-manipulation and nano-detection. Regarding the long-term goal, it is envisioned to let smart nanomaterials fulfill biological functions in cellular systems and to efficiently operate biomolecular machines in engineered environments.

Field of science

  • /social sciences/social and economic geography/transport
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /natural sciences/biological sciences/cell biology

Call for proposal

ERC-2009-StG
See other projects for this call

Funding Scheme

ERC-SG - ERC Starting Grant

Host institution

TECHNISCHE UNIVERSITAET DRESDEN
Address
Helmholtzstrasse 10
01069 Dresden
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 664 899,20
Principal investigator
Stefan Diez (Prof.)
Administrative Contact
Friederieke Noack (Ms.)

Beneficiaries (2)

TECHNISCHE UNIVERSITAET DRESDEN
Germany
EU contribution
€ 1 664 899,20
Address
Helmholtzstrasse 10
01069 Dresden
Activity type
Higher or Secondary Education Establishments
Principal investigator
Stefan Diez (Prof.)
Administrative Contact
Friederieke Noack (Ms.)
Klinik Max Planck Institut für Psychiatrie

Participation ended

Germany
EU contribution
€ 291 100,80
Address
Hofgartenstrasse 8
80539 Muenchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Birgit Knepper-Nicolai (Dr.)