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BIOmarkers of Robustness of Metabolic Homeostasis for Nutrigenomics-derived Health CLAIMS Made on Food

Objective

The food and health relationship focuses on maintenance of optimal health, both in terms of physiology and new European legislation. Yet, most accepted biomarkers quantify (intermediate) disease endpoints or damage. This has led to major problems in demonstrating health benefits and establishing health claims, and blocks competitive economic and health developments in the food sector. BIOCLAIMS develops new biomarkers by exploiting the new concept of “health biomarkers” through quantification of the robustness of the homeostatic mechanisms involved in maintaining optimal health, based on the assumption that the ability to maintain homeostasis in a continuously challenged environment and changing physiology is key for healthy ageing. Mechanisms involved will be investigated during a series of food interventions in animal models and humans using “predisposed” conditions. Human models of presumed impaired robustness in maintaining metabolic and vascular health will be employed to study the responses of established and novel biomarkers to the challenging of homeostasis and to selected food interventions. Both advanced analytical methodology including nutrigenomics tools (transcriptomics, metabolomics, fatty acid composition, adipokine profile, macromolecule damage) and “whole body” physiological assessments will be exploited to derive a series of new biomarkers. Gender differences will be addressed. BIOCLAIMS thus delivers a series of robust biomarkers predictive of a healthy metabolic phenotype during ageing, based on stressors of homeostasis, These biomarkers will be fully characterized and evaluated for practical application in human nutrition, and compared to traditional ones. The consortium consists of 11 teams, balanced in gender and geographical distribution, with track records in animal physiology, human studies in the relevant health areas, nutrigenomics and new analytical approaches, and scientific assessment of health claims in the EU.

Fields of science

Programme(s)

Topic(s)

Call for proposal

FP7-KBBE-2009-3
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Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

UNIVERSITAT DE LES ILLES BALEARS
EU contribution
€ 998 531,00
Address
CARRETERA DE VALLDEMOSSA KM 7.5
07122 Palma De Mallorca
Spain

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Region
Este Illes Balears Mallorca
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Xavier Garcias Amengual (Dr.)
Links
Total cost
No data

Participants (10)

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Last update: 16 July 2019

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Permalink: https://cordis.europa.eu/project/id/244995

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