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BIOmarkers of Robustness of Metabolic Homeostasis for Nutrigenomics-derived Health CLAIMS Made on Food

Objective

The food and health relationship focuses on maintenance of optimal health, both in terms of physiology and new European legislation. Yet, most accepted biomarkers quantify (intermediate) disease endpoints or damage. This has led to major problems in demonstrating health benefits and establishing health claims, and blocks competitive economic and health developments in the food sector. BIOCLAIMS develops new biomarkers by exploiting the new concept of “health biomarkers” through quantification of the robustness of the homeostatic mechanisms involved in maintaining optimal health, based on the assumption that the ability to maintain homeostasis in a continuously challenged environment and changing physiology is key for healthy ageing. Mechanisms involved will be investigated during a series of food interventions in animal models and humans using “predisposed” conditions. Human models of presumed impaired robustness in maintaining metabolic and vascular health will be employed to study the responses of established and novel biomarkers to the challenging of homeostasis and to selected food interventions. Both advanced analytical methodology including nutrigenomics tools (transcriptomics, metabolomics, fatty acid composition, adipokine profile, macromolecule damage) and “whole body” physiological assessments will be exploited to derive a series of new biomarkers. Gender differences will be addressed. BIOCLAIMS thus delivers a series of robust biomarkers predictive of a healthy metabolic phenotype during ageing, based on stressors of homeostasis, These biomarkers will be fully characterized and evaluated for practical application in human nutrition, and compared to traditional ones. The consortium consists of 11 teams, balanced in gender and geographical distribution, with track records in animal physiology, human studies in the relevant health areas, nutrigenomics and new analytical approaches, and scientific assessment of health claims in the EU.

Field of science

  • /medical and health sciences/basic medicine/physiology/homeostasis
  • /natural sciences/biological sciences/biochemistry/biomolecules/lipids

Call for proposal

FP7-KBBE-2009-3
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

UNIVERSITAT DE LES ILLES BALEARS
Address
Carretera De Valldemossa Km 7.5
07122 Palma De Mallorca
Spain
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 998 531
Administrative Contact
Xavier Garcias Amengual (Dr.)

Participants (10)

WAGENINGEN UNIVERSITY
Netherlands
EU contribution
€ 498 043
Address
Droevendaalsesteeg 4
6708 PB Wageningen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Martijn Gerretsen (Dr.)
CENTRE TECNOLOGIC EN TECNOLOGIES DE LA NUTRICIO I LA SALUT
Spain
EU contribution
€ 481 328
Address
Avda De La Universitat 1
43204 Reus
Activity type
Research Organisations
Administrative Contact
Lluis Arola (Prof.)
FYZIOLOGICKY USTAV AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE (VVI)
Czechia
EU contribution
€ 488 849
Address
Videnska 1083
142 20 Praha 4
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jan Kopecky (Dr.)
DEUTSCHES INSTITUT FUER ERNAEHRUNGSFORSCHUNG POTSDAM REHBRUECKE
Germany
EU contribution
€ 484 998
Address
Arthur-scheunert-allee 114-116
14558 Nuthetal
Activity type
Research Organisations
Administrative Contact
Judith Schaefer (Dr.)
UNIWERSYTET JAGIELLONSKI
Poland
EU contribution
€ 454 007
Address
Ul. Golebia 24
31 007 Krakow
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Katarzyna Gubernat (Ms.)
UNIVERSITAET GRAZ
Austria
EU contribution
€ 685 169
Address
Universitatsplatz 3
8010 Graz
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Brigitte Winklhofer-Roob (Prof.)
THE UNIVERSITY OF WARWICK
United Kingdom
EU contribution
€ 477 699
Address
Kirby Corner Road - University House
CV4 8UW Coventry
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Peter Hedges (Dr.)
UNIVERSITY OF SOUTHAMPTON
United Kingdom
EU contribution
€ 464 737
Address
Highfield
SO17 1BJ Southampton
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Yan Qiao (Ms.)
MEDIZINISCHE UNIVERSITAT GRAZ
Austria
EU contribution
€ 506 984
Address
Auenbruggerplatz 2
8036 Graz
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Johannes Roob (Prof.)
NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO
Netherlands
EU contribution
€ 458 866
Address
Anna Van Buerenplein 1
2595 DA Den Haag
Activity type
Research Organisations
Administrative Contact
Ben Van Ommen (Dr.)