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BIOmarkers of Robustness of Metabolic Homeostasis for Nutrigenomics-derived Health CLAIMS Made on Food

Obiettivo

The food and health relationship focuses on maintenance of optimal health, both in terms of physiology and new European legislation. Yet, most accepted biomarkers quantify (intermediate) disease endpoints or damage. This has led to major problems in demonstrating health benefits and establishing health claims, and blocks competitive economic and health developments in the food sector. BIOCLAIMS develops new biomarkers by exploiting the new concept of “health biomarkers” through quantification of the robustness of the homeostatic mechanisms involved in maintaining optimal health, based on the assumption that the ability to maintain homeostasis in a continuously challenged environment and changing physiology is key for healthy ageing. Mechanisms involved will be investigated during a series of food interventions in animal models and humans using “predisposed” conditions. Human models of presumed impaired robustness in maintaining metabolic and vascular health will be employed to study the responses of established and novel biomarkers to the challenging of homeostasis and to selected food interventions. Both advanced analytical methodology including nutrigenomics tools (transcriptomics, metabolomics, fatty acid composition, adipokine profile, macromolecule damage) and “whole body” physiological assessments will be exploited to derive a series of new biomarkers. Gender differences will be addressed. BIOCLAIMS thus delivers a series of robust biomarkers predictive of a healthy metabolic phenotype during ageing, based on stressors of homeostasis, These biomarkers will be fully characterized and evaluated for practical application in human nutrition, and compared to traditional ones. The consortium consists of 11 teams, balanced in gender and geographical distribution, with track records in animal physiology, human studies in the relevant health areas, nutrigenomics and new analytical approaches, and scientific assessment of health claims in the EU.

Campo scientifico

  • /scienze mediche e della salute/medicina di base/fisiologia/omeostasi
  • /scienze naturali/scienze biologiche/biochimica/biomolecole/lipidi

Invito a presentare proposte

FP7-KBBE-2009-3
Vedi altri progetti per questo bando

Meccanismo di finanziamento

CP-IP - Large-scale integrating project

Coordinatore

UNIVERSITAT DE LES ILLES BALEARS
Indirizzo
Carretera De Valldemossa Km 7.5
07122 Palma De Mallorca
Spagna
Tipo di attività
Higher or Secondary Education Establishments
Contributo UE
€ 998 531
Contatto amministrativo
Xavier Garcias Amengual (Dr.)

Partecipanti (10)

WAGENINGEN UNIVERSITY
Paesi Bassi
Contributo UE
€ 498 043
Indirizzo
Droevendaalsesteeg 4
6708 PB Wageningen
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Martijn Gerretsen (Dr.)
CENTRE TECNOLOGIC EN TECNOLOGIES DE LA NUTRICIO I LA SALUT
Spagna
Contributo UE
€ 481 328
Indirizzo
Avda De La Universitat 1
43204 Reus
Tipo di attività
Research Organisations
Contatto amministrativo
Lluis Arola (Prof.)
FYZIOLOGICKY USTAV AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE (VVI)
Cechia
Contributo UE
€ 488 849
Indirizzo
Videnska 1083
142 20 Praha 4
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Jan Kopecky (Dr.)
DEUTSCHES INSTITUT FUER ERNAEHRUNGSFORSCHUNG POTSDAM REHBRUECKE
Germania
Contributo UE
€ 484 998
Indirizzo
Arthur-scheunert-allee 114-116
14558 Nuthetal
Tipo di attività
Research Organisations
Contatto amministrativo
Judith Schaefer (Dr.)
UNIWERSYTET JAGIELLONSKI
Polonia
Contributo UE
€ 454 007
Indirizzo
Ul. Golebia 24
31 007 Krakow
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Katarzyna Gubernat (Ms.)
UNIVERSITAET GRAZ
Austria
Contributo UE
€ 685 169
Indirizzo
Universitatsplatz 3
8010 Graz
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Brigitte Winklhofer-Roob (Prof.)
THE UNIVERSITY OF WARWICK
United Kingdom
Contributo UE
€ 477 699
Indirizzo
Kirby Corner Road - University House
CV4 8UW Coventry
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Peter Hedges (Dr.)
UNIVERSITY OF SOUTHAMPTON
United Kingdom
Contributo UE
€ 464 737
Indirizzo
Highfield
SO17 1BJ Southampton
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Yan Qiao (Ms.)
MEDIZINISCHE UNIVERSITAT GRAZ
Austria
Contributo UE
€ 506 984
Indirizzo
Auenbruggerplatz 2
8036 Graz
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Johannes Roob (Prof.)
NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO
Paesi Bassi
Contributo UE
€ 458 866
Indirizzo
Anna Van Buerenplein 1
2595 DA Den Haag
Tipo di attività
Research Organisations
Contatto amministrativo
Ben Van Ommen (Dr.)