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Aberrant ubiquitin-mediated proteolysis in oncogenesis

Objective

"The ubiquitin-proteasome system controls molecular networks that underlie fundamental cellular functions such as DNA replication, DNA repair, transcription, protein synthesis, cell differentiation and apoptosis. A large body of experimental and clinical data indicates that defects in the ubiquitin-dependent protein degradation are intimately linked with cancer pathogenesis. The main objective of our research is the elucidation of the molecular mechanisms by which deregulated function of SCF ubiquitin ligases contribute to oncogenesis. To achieve our goal we propose the following aims: Aim 1. To identify novel substrates for SCF ubiquitin ligases that have been shown to play roles in tumorigenesis. Aim 2. To identify ubiquitin ligases for tumor suppressor proteins and proto-oncoproteins that are targeted by the ubiquitin-proteasome pathway. Aim 3. To determine the contribution of defective SCF-mediated degradation to cancer."

Call for proposal

FP7-PEOPLE-2009-RG
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Coordinator

KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
Address
Kloveniersburgwal 29 Het Trippenhuis
1011 JV Amsterdam
Netherlands
Activity type
Other
EU contribution
€ 100 000
Administrative Contact
Don Van Velzen (Mr.)