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Contenuto archiviato il 2024-06-18

Aberrant ubiquitin-mediated proteolysis in oncogenesis

Obiettivo

"The ubiquitin-proteasome system controls molecular networks that underlie fundamental cellular functions such as DNA replication, DNA repair, transcription, protein synthesis, cell differentiation and apoptosis. A large body of experimental and clinical data indicates that defects in the ubiquitin-dependent protein degradation are intimately linked with cancer pathogenesis. The main objective of our research is the elucidation of the molecular mechanisms by which deregulated function of SCF ubiquitin ligases contribute to oncogenesis. To achieve our goal we propose the following aims: Aim 1. To identify novel substrates for SCF ubiquitin ligases that have been shown to play roles in tumorigenesis. Aim 2. To identify ubiquitin ligases for tumor suppressor proteins and proto-oncoproteins that are targeted by the ubiquitin-proteasome pathway. Aim 3. To determine the contribution of defective SCF-mediated degradation to cancer."

Campo scientifico (EuroSciVoc)

Argomento(i)

Invito a presentare proposte

FP7-PEOPLE-2009-RG
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Meccanismo di finanziamento

MC-IRG - International Re-integration Grants (IRG)

Coordinatore

KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
Contributo UE
€ 100 000,00
Costo totale
Nessun dato