Objective
Altered fetal growth patterns, i.e. reduced growth in utero (intrauterine growth restriction, IUGR) are associated with perinatal morbidity as well as adverse consequences in adult life, e.g. cardiovascular disease. A prevailing hypothesis regarding the pathogenesis of reduced growth in utero is the “ischemic model” where abnormal placental bed vascular pathology with reduced nutrient and oxygen delivery to the intervillus space as a result of diminished placental perfusion contributes to suboptimal fetal growth in the second half of pregnancy. Amino acids are an important nutrient during fetal development and their concentration and placental transport are significantly lower in growth-restricted infants. Recent studies indicate that a variety of signals such as adenosine are produced in response to hypoxia in tissues and are higher in women with preeclampsia and growth-restricted infants. However, to date there is little information about the role of adenosine in pregnancy and the placenta. Therefore, the focus of this proposal is to investigate the effect and mechanism of the hypoxia-inducible signal adenosine on placental development and placental amino acid transport.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciencesclinical medicineobstetricsfetal medicine
- medical and health sciencesclinical medicinecardiologycardiovascular diseases
- medical and health sciencesbasic medicinepathology
- natural scienceschemical sciencesorganic chemistryamines
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Call for proposal
FP7-PEOPLE-2009-RG
See other projects for this call
Funding Scheme
MC-IRG - International Re-integration Grants (IRG)Coordinator
30625 Hannover
Germany