Objective
Faithful DNA replication and repair of DNA damage are required for genome stability and contribute to the health and survival of all organisms. Checkpoint pathways modulate DNA replication during normal cell cycles and during DNA damage repair, but little is known about the genetic and molecular determinants. The genome cycle requires DNA to be organised and manipulated, during replication, mitosis and repair. Eukaryotic genomes contain six highly conserved SMC proteins forming three types of heterodimers, which are the core of distinct multiprotein complexes involved in different aspects of DNA metabolism, including chromosome condensation and sister chromatid cohesion (Nasmyth, 2001). The Smc5/6 complex has been thought to be involved in DNA repair (Lehman n et al., 1995). However, all subunits of the complex are essential even in the absence of extrinsic DNA damage, demonstrating that this complex must have additional uncharacterised roles during some aspect of DNA metabolism. Recent studies have raised the possibility that the complex is involved in replication fork biology. The proposed research plan is aimed at testing the hypothesis that the Smc5/6 complex is directly involved in the stability of replication forks during unperturbed cell cycles and in re sponse to the DNA damaging agent hydroxyurea. To this end, I have conceived a multidisciplinary research approach that combines genetics, biochemistry and cytology in S. cerevisiae to investigate the function of this protein complex at replication forks. P rocesses related to replication fork stalling or collapse are, unsurprisingly, essential for the maintenance of genomic integrity and for the prevention of tumorigenesis. The proposed research will contribute to the understanding of genome stability and th us could ultimately be exploited to treat cancer.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine physiology cytology
- natural sciences biological sciences genetics chromosomes
- natural sciences biological sciences genetics genomes eukaryotic genomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
W12 0NN LONDON
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.