Imaging liver immunopathology by intravital microscopy (IVM): a new approach to study the pathogenesis of hepatitis B virus (HBV) infection

Informations projet

LIVER IVM AND HBV

N° de convention de subvention: 250219

Projet clôturé

Date de début 1 Septembre 2010

Date de fin 31 Mars 2016

Financé au titre de

• Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Coût total € 2 046 200,00

Contribution de l’UE € 2 046 200,00

Coordonné par

OSPEDALE SAN RAFFAELE SRL
Italy

Objectif

Overall objective and Specific Aims. The overall objective of this proposal is to elucidate the pathogenesis of
HBV infection with the ultimate hope that this knowledge will lead to the development of new therapeutic
strategies to terminate persistent infection and its attendant costs and complications. Our approach is to dissect
poorly understood cellular and molecular pathways responsible for both liver disease and viral clearance taking
advantage of technological advances in the field of live imaging and unique mouse models of HBV infection.
Three specific aims will be pursued:
1. Visualize and characterize where and how naïve and effector CTL of different specificities adhere to
vessels and recognize/kill HBV-expressing hepatocytes within the “normal”, fibrotic/cirrhotic or
cancerous liver.
2. Characterize the role of platelets in HBV pathogenesis.
3. Characterize the role of Kupffer cells in HBV pathogenesis.

Champ scientifique

• natural sciences › biological sciences › microbiology › virology
• medical and health sciences › health sciences › infectious diseases › DNA viruses › hepatitis B
• natural sciences › physical sciences › optics › microscopy
• medical and health sciences › clinical medicine › hepatology

Programme(s)

• FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thème(s)

• ERC-AG-LS6 - ERC Advanced Grant - Immunity and infection

Appel à propositions

ERC-2009-AdG
Voir d’autres projets de cet appel

Régime de financement

ERC-AG - ERC Advanced Grant

Institution d’accueil

OSPEDALE SAN RAFFAELE SRL

• Contribution de l’UE: € 1 298 620,83
• Adresse: VIA OLGETTINA 60 ; 20132 Milano ; Italie
• Région: Nord-Ovest › Lombardia › Milano
• Type d’activité: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Chercheur principal: Luca Guidotti (Prof.)
• Contact administratif: Maria Rosa Pedrazzi (Ms.)
• Coût total: Aucune donnée

Bénéficiaires (2)

OSPEDALE SAN RAFFAELE SRL

Italie

• Contribution de l’UE: € 1 298 620,83
• Adresse: VIA OLGETTINA 60 ; 20132 Milano
• Région: Nord-Ovest › Lombardia › Milano
• Type d’activité: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Chercheur principal: Luca Guidotti (Prof.)
• Contact administratif: Maria Rosa Pedrazzi (Ms.)
• Coût total: Aucune donnée

FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR

Italie

• Contribution de l’UE: € 747 579,17
• Adresse: Via Olgettina 60 ; 20132 MILANO
• Région: Nord-Ovest › Lombardia › Milano
• Type d’activité: Research Organisations
• Contact administratif: Mario Valsecchi (Mr.)
• Coût total: Aucune donnée