Final Report Summary - CED (Catalytic Enantioselective Dearomatisation : A New Strategy for the Synthesis of Complex Bioactive Natural Products)
The ability to access complex molecular frameworks from simple aromatic starting molecules makes catalytic enantioselective dearomatization (CED) a potentially powerful synthetic tool. One variation of this methodology is the 'zipper' reaction in which a linear precursor containing both the nucleophile and aldehyde is used. The aim of this project is to improve upon the initial synthesis of a model compound and investigate a 'zipper' reaction using an oxygen nucleophile in the CED process.