Skip to main content
Go to the home page of the European Commission (opens in new window)
English English
CORDIS - EU research results
CORDIS
Content archived on 2024-06-18

Role of TAM signaling in Retinal Homeostasis

Objective

Macular and retinal degeneration are common blinding conditions which affect approximately 30% of individuals aged 75 years, and pose considerable socioeconomic burden. Lack of the daily phagocytosis of photoreceptor outer segments (POS) by Retinal Pigment Epithelium (RPE) cells is the basis of such retinal degeneration (RD). This proposal aims to characterize the role of TAM receptor Tyrosine Kinase signaling in maintaining healthy retinal homeostasis. TAM receptors (Tyro3, Axl, Mer) are homeostatic regulators of the Immune, Reproductive and Nervous systems. Mer knockout mice show normal retinal structure at birth; however, at three weeks of age photoreceptors (PRs) begin to undergo apoptotic death, and by 8 weeks the entire PR population is eliminated, causing blindness. Mer mutations in rats and humans, leads to impaired vision and blindness. The two TAM ligands ProS and Gas6 are expressed in the eye. In-vitro experiments have identified Gas6 as the relevant ligand necessary to activate PR phagocytosis, but adult Gas6 KO mice have no PR degeneration, suggesting a role for ProS. To investigate whether ProS is a TAM agonist leading to PR phagocytosis, I developed a unique ProS conditional knockout mouse model. Preliminary results indicate that mice lacking ProS in the eyes show mild RD, suggesting ProS is a functional ligand in-vivo. Deleting both ligands causes severe RD, implying synergism between both ligands. This novel evidence illuminates the mechanism of TAM signaling in-vivo suggesting ligand hetero-dimerization. Using the newly generated mouse model, I propose to characterize the detailed expression pattern of TAM receptors and ligands in the eye, to establish a role for ProS in retinal homeostasis, and to utilize the unique model to better understand the TAM signaling mechanism. A linkage between ligand levels and RD will be tested, and if found, ProS and Gas6 may serve as early biomarkers for retinal degenerative disease.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.

You need to log in or register to use this function

Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

FP7-PEOPLE-2009-RG
See other projects for this call

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MC-IRG - International Re-integration Grants (IRG)

Coordinator

THE HEBREW UNIVERSITY OF JERUSALEM
EU contribution
€ 72 916,67
Address
EDMOND J SAFRA CAMPUS GIVAT RAM
91904 JERUSALEM
Israel

See on map

Activity type
Higher or Secondary Education Establishments
Links
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

No data

Participants (1)

My booklet 0 0